Robinson D S
Postgrad Med. 1975 Feb;57(2):55-62. doi: 10.1080/00325481.1975.11713963.
Many patients require multiple-drug therapy, often under the supervision of several physicians, this increasing the risk of adverse drug effects. While drug interactions cannot always be conveniently categorized, familiarity with basic pharmacologic and pharmacokinetic principles permits the clinician to anticipate and avoid many of the more common and serious drug interactions. Most serious drug interactions involve one of the four pharmacokinetic processes governing drug behavior within the body: absorption, distribution, metabolism, and renal clearance. Knowledge of whether a drug is a weak acid or a weak base is clinically useful because it can alert the physician to the propensity for certain types of drug interactions.
许多患者需要多种药物联合治疗，通常是在几位医生的监督下进行，这增加了药物不良反应的风险。虽然药物相互作用并非总能方便地分类，但熟悉基本的药理学和药代动力学原理可使临床医生预见并避免许多较常见和严重的药物相互作用。大多数严重的药物相互作用涉及体内药物行为的四个药代动力学过程之一：吸收、分布、代谢和肾清除。了解一种药物是弱酸还是弱碱在临床上很有用，因为它可以提醒医生注意某些类型药物相互作用的倾向。
