Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, 1-1, Sakai, Osaka 599-8531, Japan.
Int J Pharm. 2013 Mar 25;446(1-2):81-6. doi: 10.1016/j.ijpharm.2013.02.002. Epub 2013 Feb 10.
Hydroxyapatite (HA) is a biocompatible and porous inorganic material that can behave as an effective drug carrier. In this study, HA nanoparticles were prepared according to the hydrothermal method and used as a drug carrier for a water-insoluble anticancer drug, paclitaxel (Tax). The absorption of Tax onto the HA was dependent on the solvent composition. The Tax-loaded HA (Tax/HA) exhibited a lower level of activity than the free Tax because the HA material was not stably dispersed in aqueous media. The Tax/HA was therefore embedded in a collagen gel to give the Tax/HA-embedded collagen gel (Tax/HA/Col), which exhibited a higher level of activity than the Tax-containing collagen gel (Tax/Col). Interestingly, the highly metastatic MDA-MB-231 cells were more sensitive to the Tax/HA/Col than the poorly metastatic MCF-7 cells. Tax/HA/Col is therefore useful for the drug delivery into metastatic cancer cells.
羟基磷灰石（HA）是一种生物相容性和多孔的无机材料，可以作为有效的药物载体。在这项研究中，根据水热法制备了 HA 纳米粒子，并将其用作一种水不溶性抗癌药物紫杉醇（Tax）的药物载体。Tax 在 HA 上的吸附取决于溶剂组成。负载 Tax 的 HA（Tax/HA）的活性低于游离 Tax，因为 HA 材料在水介质中不能稳定分散。因此，将 Tax/HA 嵌入胶原凝胶中得到 Tax/HA 嵌入胶原凝胶（Tax/HA/Col），其活性高于含 Tax 的胶原凝胶（Tax/Col）。有趣的是，高转移性 MDA-MB-231 细胞比低转移性 MCF-7 细胞对 Tax/HA/Col 更为敏感。因此，Tax/HA/Col 可用于将药物递送至转移性癌细胞。
