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Gain-of-function STAT1 mutations are associated with PD-L1 overexpression and a defect in B-cell survival.

作者信息

Romberg Neil, Morbach Henner, Lawrence Monica G, Kim Sanghyun, Kang Insoo, Holland Steven M, Milner Joshua D, Meffre Eric

出版信息

J Allergy Clin Immunol. 2013 Jun;131(6):1691-3. doi: 10.1016/j.jaci.2013.01.004. Epub 2013 Feb 10.

DOI:10.1016/j.jaci.2013.01.004
PMID:23403048
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3672340/
Abstract
摘要

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本文引用的文献

1
Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1.白细胞介素-27 预先刺激 T 细胞通过诱导配体 PD-L1 反式控制白细胞介素-17 的产生。
Immunity. 2012 Jun 29;36(6):1017-30. doi: 10.1016/j.immuni.2012.03.024. Epub 2012 Jun 21.
2
Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis.功能获得性人类 STAT1 突变会损害 IL-17 免疫，并导致慢性黏膜皮肤念珠菌病。
J Exp Med. 2011 Aug 1;208(8):1635-48. doi: 10.1084/jem.20110958. Epub 2011 Jul 4.
3
STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis.常染色体显性遗传慢性黏膜皮肤念珠菌病中的 STAT1 突变。
N Engl J Med. 2011 Jul 7;365(1):54-61. doi: 10.1056/NEJMoa1100102. Epub 2011 Jun 29.
4
Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome.常染色体显性高免疫球蛋白E综合征患者中辅助性T细胞17（TH17）细胞分化受损。
Nature. 2008 Apr 10;452(7188):773-6. doi: 10.1038/nature06764. Epub 2008 Mar 12.
5
STAT1-induced apoptosis is mediated by caspases 2, 3, and 7.信号转导和转录激活因子1（STAT1）诱导的细胞凋亡由半胱天冬酶2、3和7介导。
J Biol Chem. 2004 Feb 6;279(6):4066-74. doi: 10.1074/jbc.M307774200. Epub 2003 Nov 17.
6
Human B-cell lymphoma cell lines are highly sensitive to apoptosis induced by all-trans retinoic acid and interferon-gamma.人B细胞淋巴瘤细胞系对全反式维甲酸和γ干扰素诱导的凋亡高度敏感。
Leuk Res. 2002 Aug;26(8):745-55. doi: 10.1016/s0145-2126(01)00202-8.
7
Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1.由STAT1介导的细胞生长停滞及细胞周期蛋白依赖性激酶抑制剂p21 WAF1/CIP1的诱导。
Science. 1996 May 3;272(5262):719-22. doi: 10.1126/science.272.5262.719.