Department of Neurosurgery, Università Politecnica delle Marche, Umberto I General Hospital, Ancona, Italy.
Cancer Manag Res. 2013;5:21-4. doi: 10.2147/CMAR.S38768. Epub 2013 Jan 30.
Giant cell tumors (GCTs) are primary bone neoplasms that rarely involve the skull base. These lesions are usually locally aggressive and require complete removal, including the surrounding apparently healthy bone, to provide the best chance of cure. GCTs, as well as other lesions located in the clivus, can nowadays be treated by a minimally invasive fully endoscopic extended endonasal approach. This approach ensures a more direct route to the craniovertebral junction than other possible approaches (transfacial, extended lateral, and posterolateral approaches). The case reported is a clival GCT operated on by an extended endonasal approach that provides another contribution on how to address one of the most feared complications attributed to this approach: a massive bleed due to an internal carotid artery injury.
巨细胞瘤（GCTs）是一种罕见累及颅底的原发性骨肿瘤。这些病变通常具有局部侵袭性，需要完全切除，包括周围看似正常的骨组织，以提供最佳治愈机会。GCT 以及其他位于斜坡的病变，现在可以通过微创的完全内窥镜扩大经鼻入路进行治疗。与其他可能的入路（经面、扩展侧方和后外侧入路）相比，该入路可确保更直接到达颅颈交界区。本报告病例为经扩大经鼻入路治疗的斜坡 GCT，为解决该入路最可怕的并发症之一（颈内动脉损伤导致的大出血）提供了另一种方法。
