Zhang Wenjie, Zhao Weiwei, Jia Zhiyun, Deng Houfu
Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, P.R. China.
Exp Ther Med. 2013 Feb;5(2):608-610. doi: 10.3892/etm.2012.807. Epub 2012 Nov 12.
Prostate cancer is a growing public health problem. The palliation of pain in patients with painful bone metastases is of primary importance in the clinical management of advanced cancer. Internal therapy with radionuclides, which concentrate at sites of increased bone turnover, is used to control pain and improve quality of life as an alternative to conventional therapies. In the present study, we report the case of a 52-year-old male who had been diagnosed with prostate cancer. The patient presented with severe pain in multiple areas, but particularly in the right hip. A whole-body bone scan revealed that the right hip, ilium and ischium were covered with huge metastatic lesions. Treatment with radionuclide strontium-89 chloride ((89)Sr) resulted in a partial response which was confirmed by the successful relief of pain and other imaging modalities. No significant change in the leukocyte or thrombocyte levels was observed. The results of the present study indicate that systemic radionuclide therapy using (89)Sr is an effective, well-tolerated and safe palliative treatment in patients with huge osseous metastases in prostate carcinoma.
前列腺癌是一个日益严重的公共卫生问题。在晚期癌症的临床管理中，缓解伴有骨转移疼痛患者的疼痛至关重要。放射性核素内治疗可聚集在骨转换增加的部位，作为传统疗法的替代方法，用于控制疼痛并改善生活质量。在本研究中，我们报告了一例52岁男性前列腺癌患者的病例。该患者多处出现剧痛，尤其是右髋部。全身骨扫描显示右髋、髂骨和坐骨布满巨大的转移病灶。用放射性核素氯化锶-89（89Sr）治疗产生了部分缓解，疼痛成功缓解及其他影像学检查证实了这一点。未观察到白细胞或血小板水平有显著变化。本研究结果表明，使用89Sr进行全身放射性核素治疗对前列腺癌伴巨大骨转移患者是一种有效、耐受性良好且安全的姑息治疗方法。
