神经退行性疾病中的小胶质细胞-神经元相互作用。
Microglial-neuronal interactions during neurodegenerative diseases.
机构信息
Neurology, Duke University Medical Center, Box 2900, Durham, NC 27710, USA.
出版信息
J Neuroimmune Pharmacol. 2013 Mar;8(1):4-6. doi: 10.1007/s11481-013-9437-9. Epub 2013 Feb 13.
Abstract
The impact of the brain's immune response to disease is no longer relegated to a secondary event of limited interest. Multiple types of brain and spinal cord injuries and diseases show varying immune phenotypes over the time course of the disease. The collection of articles illustrates the wide reach of brain immunity and provides research papers and reviews that illustrate this point. These articles have added both new information and new directions to consider, and I would like to thank all of the participants for their insightful contributions to the field.
摘要
大脑对疾病的免疫反应的影响不再局限于一个次要的、有限兴趣的事件。多种类型的脑和脊髓损伤及疾病在疾病的病程中表现出不同的免疫表型。这些文章展示了广泛的脑免疫，并提供了研究论文和综述，说明了这一点。这些文章不仅增加了新的信息，还提出了新的研究方向，我要感谢所有参与者对该领域的深刻贡献。
相似文献
1
Microglial-neuronal interactions during neurodegenerative diseases.神经退行性疾病中的小胶质细胞-神经元相互作用。
J Neuroimmune Pharmacol. 2013 Mar;8(1):4-6. doi: 10.1007/s11481-013-9437-9. Epub 2013 Feb 13.
2
Microglia in Neurodegenerative Disorders.神经退行性疾病中的小胶质细胞
Methods Mol Biol. 2019;2034:57-67. doi: 10.1007/978-1-4939-9658-2_5.
3
Immune phenotypes of microglia in human neurodegenerative disease: challenges to detecting microglial polarization in human brains.人类神经退行性疾病中小胶质细胞的免疫表型：检测人类大脑中小胶质细胞极化的挑战
Alzheimers Res Ther. 2015 Aug 19;7(1):56. doi: 10.1186/s13195-015-0139-9.
4
Debris clearance by microglia: an essential link between degeneration and regeneration.小胶质细胞清除碎片：退变与再生之间的关键联系。
Brain. 2009 Feb;132(Pt 2):288-95. doi: 10.1093/brain/awn109. Epub 2008 Jun 20.
5
Microglia-Specific Metabolic Changes in Neurodegeneration.小胶质细胞特异性代谢变化与神经退行性变。
J Mol Biol. 2019 Apr 19;431(9):1830-1842. doi: 10.1016/j.jmb.2019.03.006. Epub 2019 Mar 13.
6
Microglia and neuroprotection: from in vitro studies to therapeutic applications.小胶质细胞与神经保护：从体外研究到治疗应用。
Prog Neurobiol. 2010 Nov;92(3):293-315. doi: 10.1016/j.pneurobio.2010.06.009. Epub 2010 Jul 4.
7
The immunology of neurodegeneration.神经退行性变的免疫学。
J Clin Invest. 2012 Apr;122(4):1156-63. doi: 10.1172/JCI58656. Epub 2012 Apr 2.
8
Microglial cell origin and phenotypes in health and disease.小胶质细胞在健康和疾病中的起源和表型。
Nat Rev Immunol. 2011 Oct 25;11(11):775-87. doi: 10.1038/nri3086.
9
Role of Microglia in Modulating Adult Neurogenesis in Health and Neurodegeneration.小胶质细胞在调节健康和神经退行性变中的成年神经发生中的作用。
Int J Mol Sci. 2020 Sep 19;21(18):6875. doi: 10.3390/ijms21186875.
10
Exploring the Significance of Microglial Phenotypes and Morphological Diversity in Neuroinflammation and Neurodegenerative Diseases: From Mechanisms to Potential Therapeutic Targets.探讨小胶质细胞表型和形态多样性在神经炎症和神经退行性疾病中的意义：从机制到潜在治疗靶点。
Immunol Invest. 2024 Aug;53(6):891-946. doi: 10.1080/08820139.2024.2358446. Epub 2024 Jun 5.
引用本文的文献
1
The role of the immunoproteasome in interferon-γ-mediated microglial activation.免疫蛋白酶体在干扰素-γ介导的小胶质细胞活化中的作用。
Sci Rep. 2017 Aug 24;7(1):9365. doi: 10.1038/s41598-017-09715-y.
2
Signaling and stress: The redox landscape in NOS2 biology.信号传导与应激：一氧化氮合酶2生物学中的氧化还原格局
Free Radic Biol Med. 2015 Oct;87:204-25. doi: 10.1016/j.freeradbiomed.2015.06.002. Epub 2015 Jun 24.
3
The nervous and the immune systems: conspicuous physiological analogies.神经系统与免疫系统：显著的生理相似性。
J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2015 Feb;201(2):185-94. doi: 10.1007/s00359-014-0961-8. Epub 2014 Nov 15.
4
Intrathecal antagonism of microglial TLR4 reduces inflammatory damage to blood-spinal cord barrier following ischemia/reperfusion injury in rats.大鼠缺血/再灌注损伤后，小胶质细胞Toll样受体4的鞘内拮抗作用可减轻对血脊髓屏障的炎性损伤。
Mol Brain. 2014 Apr 21;7:28. doi: 10.1186/1756-6606-7-28.
5
Immunomodulatory function of κ-carrageenan oligosaccharides acting on LPS-activated microglial cells.κ-卡拉胶寡糖对 LPS 激活的小胶质细胞的免疫调节作用。
Neurochem Res. 2014 Feb;39(2):333-43. doi: 10.1007/s11064-013-1228-4. Epub 2013 Dec 20.
6
Two novel mutations in ABHD12: expansion of the mutation spectrum in PHARC and assessment of their functional effects.两种新型 ABHD12 突变：PHARC 突变谱的扩展及其功能影响评估。
Hum Mutat. 2013 Dec;34(12):1672-8. doi: 10.1002/humu.22437. Epub 2013 Oct 2.
本文引用的文献
1
Immune heterogeneity in neuroinflammation: dendritic cells in the brain.神经炎症中的免疫异质性：大脑中的树突状细胞。
J Neuroimmune Pharmacol. 2013 Mar;8(1):145-62. doi: 10.1007/s11481-012-9414-8. Epub 2012 Nov 1.
2
Microglial activation and antioxidant responses induced by the Parkinson's disease protein α-synuclein.帕金森病蛋白α-突触核蛋白诱导的小胶质细胞激活和抗氧化反应。
J Neuroimmune Pharmacol. 2013 Mar;8(1):94-117. doi: 10.1007/s11481-012-9401-0. Epub 2012 Oct 10.
3
Behaviour and hippocampus-specific changes in spiny mouse neonates after treatment of the mother with the viral-mimetic Poly I:C at mid-pregnancy.孕期中期用病毒模拟物 Poly I:C 处理母鼠后，刺鼠幼仔的行为和海马特异性变化。
Brain Behav Immun. 2012 Nov;26(8):1288-99. doi: 10.1016/j.bbi.2012.08.011. Epub 2012 Aug 29.
4
Resolvin E1 inhibits neuropathic pain and spinal cord microglial activation following peripheral nerve injury.解析素 E1 抑制外周神经损伤后的神经病理性疼痛和脊髓小胶质细胞激活。
J Neuroimmune Pharmacol. 2013 Mar;8(1):37-41. doi: 10.1007/s11481-012-9394-8. Epub 2012 Aug 10.
5
Antagonism of neuronal prostaglandin E(2) receptor subtype 1 mitigates amyloid β neurotoxicity in vitro.神经元前列腺素 E(2)受体亚型 1 的拮抗作用可减轻体外淀粉样 β 神经毒性。
J Neuroimmune Pharmacol. 2013 Mar;8(1):87-93. doi: 10.1007/s11481-012-9380-1. Epub 2012 Jun 21.
6
Anti-viral and anti-inflammatory mechanisms of the innate immune transcription factor interferon regulatory factor 3: relevance to human CNS diseases.先天免疫转录因子干扰素调节因子 3 的抗病毒和抗炎机制：与人类中枢神经系统疾病的相关性。
J Neuroimmune Pharmacol. 2013 Mar;8(1):132-44. doi: 10.1007/s11481-012-9360-5. Epub 2012 Jun 10.
7
Impact of prenatal immune system disturbances on brain development.产前免疫系统紊乱对大脑发育的影响。
J Neuroimmune Pharmacol. 2013 Mar;8(1):79-86. doi: 10.1007/s11481-012-9374-z. Epub 2012 May 13.
8
Microglial SK3 and SK4 currents and activation state are modulated by the neuroprotective drug, riluzole.小胶质细胞 SK3 和 SK4 电流及其激活状态受神经保护药物利鲁唑的调节。
J Neuroimmune Pharmacol. 2013 Mar;8(1):227-37. doi: 10.1007/s11481-012-9365-0. Epub 2012 Apr 19.
9
When human immunodeficiency virus meets chemokines and microglia: neuroprotection or neurodegeneration?当人类免疫缺陷病毒遇到趋化因子和小胶质细胞时：是神经保护还是神经退行性变？
J Neuroimmune Pharmacol. 2013 Mar;8(1):118-31. doi: 10.1007/s11481-012-9353-4. Epub 2012 Apr 15.
10
Roles of activated microglia in hypoxia induced neuroinflammation in the developing brain and the retina.激活的小胶质细胞在缺氧诱导的发育中脑和视网膜神经炎症中的作用。
J Neuroimmune Pharmacol. 2013 Mar;8(1):66-78. doi: 10.1007/s11481-012-9347-2. Epub 2012 Feb 26.
Zotero 插件