Strauss P
Centra fyziologických vied SAV v Bratislave.
Bratisl Lek Listy. 1990 Mar;91(3):208-12.
The effect of gamma-aminobutyric acid (GABA) on its receptors localized on the somatic and dendritic membrane of Purkinje cells was tested on the isolated cerebellum of the frog. The action of GABA was found to be different in the two zones studied. On the membrane of the cell bodies GABA inhibited the overall synaptic potential and spontaneous activity by a mechanism dependent on increased Cl- conductivity resulting in hyperpolarization of the somatic membrane. On the dendritic membrane the inhibitory effect of GABA on the spontaneous activity of dendrites was only minimal and shortlasting. At intradendritic recording a depolarizing effect of GABA was observed whose mechanism is so far unknown.
在青蛙的离体小脑中测试了γ-氨基丁酸（GABA）对位于浦肯野细胞体膜和树突膜上的其受体的作用。发现GABA在所研究的两个区域中的作用不同。在细胞体膜上，GABA通过一种依赖于氯离子电导率增加导致体细胞膜超极化的机制来抑制整体突触电位和自发活动。在树突膜上，GABA对树突自发活动的抑制作用仅为最小且持续时间短。在树突内记录时，观察到GABA有去极化作用，其机制目前尚不清楚。
