2号染色体短臂2区3带缺失（del(2)(p23)）：急性髓系白血病中一种新的复发性异常。
del(2)(p23): a new recurrent abnormality in acute myeloid leukemia.
作者信息
Najfeld V, Scalise A, Fruchtman S, Troy K
机构信息
Tumor Cytogenetics Laboratory, Polly Annenberg Levee Hematology Center, Mount Sinai Medical Center, New York, New York 10029.
出版信息
Cancer Genet Cytogenet. 1990 Jun;46(2):185-90. doi: 10.1016/0165-4608(90)90103-h.
In two patients with acute myeloid leukemia, we found a new chromosome abnormality: del(2)(p23) which was detected in 13% and 50% of studied bone marrow cells, respectively. In patient one, del(2p) was an additional abnormality to t(8;21), while patient two had del(2p) as the sole abnormality. Based on our observation and a review of the literature we propose that del(2p) is a new recurrent chromosome abnormality for acute myeloid leukemia.
在两名急性髓系白血病患者中，我们发现了一种新的染色体异常：del(2)(p23)，分别在13%和50%的研究骨髓细胞中检测到。在患者一中，del(2p)是t(8;21)之外的另一种异常，而患者二则以del(2p)作为唯一异常。基于我们的观察以及文献回顾，我们提出del(2p)是急性髓系白血病一种新的复发性染色体异常。
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