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来自中国北京一名患心肌炎儿童的人柯萨奇病毒B3全基因组序列

Complete genome sequence of a human coxsackievirus b3 from a child with myocarditis in beijing, china.

作者信息

Du Jiang, Wu Zhiqiang, Xue Ying, Zhang Ting, Yang Fan, Jin Qi

机构信息

MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.

出版信息

Genome Announc. 2013 Jan;1(1). doi: 10.1128/genomeA.00163-12. Epub 2013 Feb 7.

Abstract

A human coxsackievirus B3 (CVB3), designated strain Beijing0811, was isolated from a child diagnosed with hospital-acquired infectious acute myocarditis in Beijing, China, and propagated in human rhabdomyosarcoma cells. The complete genome sequence of this virus was 7,402 nucleotides, excluding the 3' poly(A) tail, which encoded a large polyprotein with 2,185 amino acids. This report will help us to analyze the evolutionary and epidemic characteristics of CVB3.

摘要

一株人柯萨奇病毒B3(CVB3),命名为北京0811株,从中国北京一名被诊断为医院获得性感染性急性心肌炎的儿童体内分离得到,并在人横纹肌肉瘤细胞中增殖。该病毒的全基因组序列为7402个核苷酸,不包括3' 聚腺苷酸尾,编码一个含有2185个氨基酸的大的多聚蛋白。本报告将有助于我们分析CVB3的进化和流行特征。

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