犬呼吸道冠状病毒的全基因组分析
Complete genome analysis of canine respiratory coronavirus.
作者信息
Lim Seong-In, Choi Sarah, Lim Ji-Ae, Jeoung Hye-Young, Song Jae-Young, Dela Pena R C, An Dong-Jun
机构信息
Animal, Plant, and Fisheries Quarantine and Inspection Agency, Anyang, Gyeonggi, Republic of Korea.
出版信息
Genome Announc. 2013 Jan;1(1). doi: 10.1128/genomeA.00093-12. Epub 2013 Jan 31.
The canine respiratory coronavirus (CRCoV) K37 strain of the family Coronaviridae, group 2, was isolated in South Korea. Its genome was analyzed by nucleotide sequencing and was determined to have 31,029 bp. The small open reading frames situated between the spike and envelope genes of most of the CRCoV strains (except the CRCoV 4180 strain) were found to encode three nonstructural proteins (4.9 kDa, 2.7 kDa, and 12.8 kDa), while those of bovine coronavirus (BCoV) encode another three nonstructural proteins (4.9 kDa, 4.8 kDa, and 12.7 kDa) and those of a recently isolated bovine respiratory coronavirus (BRCoV) were found to encode only two nonstructural proteins (4.9 kDa and 12.7 kDa). The differences in the genes encoding these small nonstructural proteins may be associated with the emergence of highly similar viruses in different hosts.
犬呼吸道冠状病毒（CRCoV）K37株属于冠状病毒科第2组，在韩国被分离出来。通过核苷酸测序对其基因组进行了分析，确定其基因组大小为31,029 bp。发现大多数CRCoV毒株（CRCoV 4180毒株除外）的刺突基因和包膜基因之间的小开放阅读框编码三种非结构蛋白（4.9 kDa、2.7 kDa和12.8 kDa），而牛冠状病毒（BCoV）的小开放阅读框编码另外三种非结构蛋白（4.9 kDa、4.8 kDa和12.7 kDa），并且最近分离出的牛呼吸道冠状病毒（BRCoV）的小开放阅读框仅编码两种非结构蛋白（4.9 kDa和12.7 kDa）。编码这些小非结构蛋白的基因差异可能与不同宿主中高度相似病毒的出现有关。
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