Kato K, Nakagaki H, Robinson C, Weatherell J A
Department of Preventive Dentistry and Dental Public Health, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.
Caries Res. 1990;24(2):117-20. doi: 10.1159/000261251.
This study was undertaken to determine the fluoride distribution in cementum and neighboring hard tissues of the rat after different levels of fluoride administration via the drinking water. Specimens of cementum with underlying dentine and adjacent bone were removed from the distal roots of the first lower molars. The fluoride distribution in each specimen was determined in samples removed sequentially using an abrasive microsampling technique. Fluoride concentrations were highest at or near the surface and decreased towards the interior of cementum, dentine and alveolar bone in both control and experimental groups. With increasing fluoride intake, concentrations increased throughout the tissue. The distribution patterns of fluoride in cementum of contralateral teeth from the same animal were similar. Fluoride concentrations in cementum were higher than those of dentine and alveolar bone.
本研究旨在确定通过饮用水给予不同剂量氟化物后，大鼠牙骨质及邻近硬组织中的氟分布情况。从第一下颌磨牙远中根取出含有下方牙本质和相邻骨组织的牙骨质标本。使用研磨微取样技术，对依次取出的样本进行检测，以确定每个标本中的氟分布。对照组和实验组中，氟浓度在牙骨质、牙本质和牙槽骨的表面或其附近最高，向内部逐渐降低。随着氟摄入量的增加，整个组织中的氟浓度升高。同一动物对侧牙齿牙骨质中的氟分布模式相似。牙骨质中的氟浓度高于牙本质和牙槽骨中的氟浓度。
