Bornstein S R, Ehrhart M, Scherbaum W A, Pfeiffer E F
Innere Medizin I, Universität Ulm, Federal Republic of Germany.
Cell Tissue Res. 1990 Apr;260(1):161-6. doi: 10.1007/BF00297501.
The effects of high dose injections of corticotropin-releasing hormone (CRH) on the adrenal cortex of hypophysectomized rats were studied at the light- and electron-microscopical levels. Adrenocortical atrophy induced by hypophysectomy could be reduced by daily i.p. injection of 10 micrograms (3 nmol) CRH given for 3 days starting at day 5 after the operation. The cortex broadened, mostly because of hypertrophy of the zona fasciculata. Blood vessels were enlarged. Although the adrenocortical cells of hypophysectomized rats showed features of a functionally suppressed state, such as tubular mitochondria, the cells of CRH-treated animals showed characteristics of stimulated cells. The inner membrane of the mitochondria formed the typical densely packed vesicles of adrenocortical cells that are active in steroidogenesis. Lipid droplets were found to be reduced, and the cells developed filopodia at their surface. These morphological observations indicate that CRH influences the adrenal cortex via extrapituitary mechanisms.
在光镜和电镜水平上研究了大剂量注射促肾上腺皮质激素释放激素（CRH）对垂体切除大鼠肾上腺皮质的影响。垂体切除引起的肾上腺皮质萎缩可通过术后第5天开始连续3天每天腹腔注射10微克（3纳摩尔）CRH来减轻。皮质变宽，主要是因为束状带肥大。血管增大。虽然垂体切除大鼠的肾上腺皮质细胞表现出功能抑制状态的特征，如管状线粒体，但接受CRH治疗的动物的细胞表现出受刺激细胞的特征。线粒体的内膜形成了在类固醇生成中活跃的肾上腺皮质细胞典型的紧密堆积的小泡。发现脂滴减少，细胞表面形成丝状伪足。这些形态学观察表明，CRH通过垂体外机制影响肾上腺皮质。
