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评估ST段抬高型心肌梗死后的心肌恢复:使用心血管磁共振的短期和长期观点

Assessing myocardial recovery following ST-segment elevation myocardial infarction: short- and long-term perspectives using cardiovascular magnetic resonance.

作者信息

Klug Gert, Metzler Bernhard

机构信息

University Clinic of Internal Medicine III (Cardiology), Medical University of Innsbruck, Innsbruck, Austria.

出版信息

Expert Rev Cardiovasc Ther. 2013 Feb;11(2):203-19. doi: 10.1586/erc.12.173.

Abstract

Myocardial recovery after revascularization for ST-segment elevation myocardial infarction (STEMI) remains a significant diagnostic and, despite novel treatment strategies, a therapeutic challenge. Cardiovascular magnetic resonance (CMR) has emerged as a valuable clinical and research tool after acute STEMI. It represents the gold standard for functional and morphological evaluation of the left ventricle. Gadolinium-based perfusion and late-enhancement viability imaging has expanded our knowledge about the underlying pathologies of inadequate myocardial recovery. T2-weighted imaging of myocardial salvage after early reperfusion of the infarct-related artery underlines the effectiveness of current invasive treatment for STEMI. In the last decade, the number of publications on CMR after acute STEMI continued to rise, with no plateau in sight. Currently, CMR research is gathering robust prognostic data on standardized CMR protocols with the aim to substantially improve patient care and prognosis. Beyond established CMR protocols, more specific methods such as magnetic resonance relaxometry, myocardial tagging, 4D phase-contrast imaging and novel superparamagnetic contrast agents are emerging. This review will discuss the currently available data on the use of CMR after acute STEMI and take a brief look at developing new methods currently under investigation.

摘要

ST段抬高型心肌梗死(STEMI)血管重建术后的心肌恢复仍然是一个重大的诊断难题,并且尽管有新的治疗策略,仍是一个治疗挑战。心血管磁共振(CMR)已成为急性STEMI后一种有价值的临床和研究工具。它是左心室功能和形态学评估的金标准。基于钆的灌注和延迟强化存活心肌成像扩展了我们对心肌恢复不足潜在病理的认识。梗死相关动脉早期再灌注后心肌挽救的T2加权成像突出了当前STEMI侵入性治疗的有效性。在过去十年中,关于急性STEMI后CMR的出版物数量持续上升,未见平稳趋势。目前,CMR研究正在收集关于标准化CMR方案的有力预后数据,旨在大幅改善患者护理和预后。除了既定的CMR方案,诸如磁共振弛豫测量法、心肌标记、4D相位对比成像和新型超顺磁性造影剂等更具特异性的方法正在出现。本综述将讨论急性STEMI后使用CMR的现有数据,并简要介绍目前正在研究的新方法。

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