滤泡辅助性 T 细胞（Tfh）的转录调控。
Transcriptional regulation of follicular T-helper (Tfh) cells.
机构信息
Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, TX 77054, USA.
出版信息
Immunol Rev. 2013 Mar;252(1):139-45. doi: 10.1111/imr.12040.
Abstract
T-follicular helper (Tfh) cells are a new subset of effector CD4(+) T cells that are specialized in helping B cells in the germinal center reaction. Tfh cells are distinct from other established CD4(+) T-cell lineages, Th1, Th2, Th17, and T-regulatory cells, in their gene expression profiles. Tfh cell differentiation results from a network of transcriptional regulation by a master transcriptional factor Bcl6 as well as IRF4, c-Maf, Batf, and STAT3/5. During Tfh cell ontogeny, increased CXCR5 expression directs activated T-cell migration to the follicles, and their interaction with B cells leads to Bcl6 upregulation, which helps establish effector and memory Tfh cell program. This review summarizes the recent progress in molecular mechanisms underlying Tfh differentiation and discusses the future perspectives for this important area of research.
摘要
滤泡辅助性 T 细胞（Tfh）是效应性 CD4+T 细胞的一个新亚群，专门在生发中心反应中辅助 B 细胞。Tfh 细胞在其基因表达谱上有别于其他已建立的 CD4+T 细胞谱系，如 Th1、Th2、Th17 和 T 调节细胞。Tfh 细胞的分化是由转录因子 Bcl6 以及 IRF4、c-Maf、Batf 和 STAT3/5 的转录调控网络所导致的。在 Tfh 细胞发生过程中，CXCR5 表达的增加指导激活的 T 细胞向滤泡迁移，它们与 B 细胞的相互作用导致 Bcl6 的上调，这有助于建立效应器和记忆性 Tfh 细胞程序。本综述总结了 Tfh 分化的分子机制的最新进展，并讨论了这一重要研究领域的未来展望。
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