Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637, United States.
J Am Chem Soc. 2013 Mar 6;135(9):3411-3. doi: 10.1021/ja401182a. Epub 2013 Feb 19.
An efficient and versatile method for the enantioselective epoxidation of both tertiary allylic and homoallylic alcohols catalyzed by Hf(IV)-bishydroxamic acid (BHA) complexes is described. Asymmetric epoxidation, kinetic resolution, and desymmetrization have been developed, demonstrating the flexible nature of the Hf(IV)-BHA system. This is the first report in which these substrates were obtained with enantioselectivities of up to 99%.
本文描述了由 Hf(IV)-双羟肟酸(BHA)配合物催化的对三级烯丙基和同烯丙基醇的对映选择性环氧化的高效且通用的方法。已开发出不对称环氧化、动力学拆分和去对称化,证明了 Hf(IV)-BHA 体系的灵活性。这是首次报道这些底物的对映选择性高达 99%。