Institute for Occupational Medicine, Charité Universitätsmedizin Berlin, Thielallee 69, Berlin D-14195, Germany.
J Occup Med Toxicol. 2013 Feb 13;8(1):2. doi: 10.1186/1745-6673-8-2.
We have investigated the relationship between atopic status and long-term occupational exposure to latex proteins or methyl diethyl diisocyanate (MDI) as high and low molecular weight asthma-inducing agents, respectively.
This study is based on retrospective analyses of two groups of symptomatic outpatients: 184 healthcare workers with latex exposure and 156 workers with isocyanate (MDI) exposure. We analysed atopic and non-atopic subgroups according to exposure duration and the frequencies of specific sensitization.
45% of the healthcare subgroup specifically sensitized to latex were atopic, whereas in the non-sensitized healthcare subgroup only 26% were atopic. On the other hand, subjects specifically sensitized to MDI were rarely atopic (only 15%), whereas in the subgroup non-sensitized to MDI atopy was present in 38%. After prolonged durations of exposure, the proportion of atopics was further elevated in most healthcare subgroups but it decreased in the MDI-exposed subjects.
We hypothesize that latex proteins as sensitizing agents might promote the development of atopy, whereas exposure to the low molecular weight MDI might inhibit the atopic status.
我们研究了特应性状态与长期职业暴露于乳胶蛋白或甲基二乙基二异氰酸酯（MDI）之间的关系，分别将它们视为高和低分子量的哮喘诱导剂。
本研究基于对两组有症状门诊患者的回顾性分析：184 名乳胶暴露的医护人员和 156 名异氰酸酯（MDI）暴露的工人。我们根据暴露时间和特定致敏的频率分析了特应性和非特应性亚组。
45%的乳胶特异性致敏的医护亚组是特应性的，而非致敏的医护亚组中只有 26%是特应性的。另一方面，特异性致敏于 MDI 的受试者很少是特应性的（仅为 15%），而非 MDI 特异性致敏的亚组中则有 38%是特应性的。在长时间暴露后，大多数医护亚组中特应性的比例进一步升高，但在 MDI 暴露的受试者中则降低。
我们假设乳胶蛋白作为致敏剂可能会促进特应性的发展，而接触低分子量的 MDI 可能会抑制特应性状态。
