（+）-软珊瑚醇内酯 C 的两种可能非对映异构体的全合成及其结构阐明。
Total synthesis of two possible diastereomers of (+)-sarcophytonolide C and its structural elucidation.
机构信息
Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushimanaka, Kita-ku, Okayama 700-8530, Japan.
出版信息
Org Lett. 2013 Mar 1;15(5):1108-11. doi: 10.1021/ol400157s. Epub 2013 Feb 13.
Stereoselective and parallel total syntheses of two possible diastereomers of (+)-sarcophytonolide C have been accomplished. Macrolactonization and transannular ring-closing metathesis (RCM) were the key transformations. Detailed comparisons of their (1)H and (13)C NMR data and specific rotation with those of the natural product allowed the absolute configuration of (+)-sarcophytonolide C to be determined.
已经完成了（+）-软珊瑚内酯 C 的两种可能非对映异构体的对映选择性和并行全合成。大环内酯化和反式环封环易位（RCM）是关键转化。与天然产物的（1）H 和（13）C NMR 数据和比旋光度的详细比较，确定了（+）-软珊瑚内酯 C 的绝对构型。
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