曲马多和文拉法辛联合使用——评估其在大鼠中的抗抑郁样活性和其他行为效应。

Concomitant use of tramadol and venlafaxine - evaluation of antidepressant-like activity and other behavioral effects in rats.

机构信息

Department of Clinical Pharmacy and Biopharmacy, Poznan University of Medical Sciences, Sw. Marii Magdaleny 14, PL 61-861 Poznań, Poland.

出版信息

Pharmacol Rep. 2012;64(6):1350-8. doi: 10.1016/s1734-1140(12)70932-5.

DOI:10.1016/s1734-1140(12)70932-5

PMID:23406745

Abstract

BACKGROUND

The aim of this study was to evaluate antidepressant-like effect (Porsolt test), locomotor activity and motor coordination of joint administration of tramadol (TRM) and venlafaxine (VEN) in rats.

METHODS

The tests were performed on male Wistar rats after single and chronic treatment (7 and 14 days) with TRM intraperitoneally (ip) and VEN orally (po) administered once a day. The controls were given 0.5% carboxymethylcellulose (CMC) solution (0.5 ml per rat, ip and po).

RESULTS

It was found that combination of TRM (5 mg/kg ip) with VEN (20 mg/kg po) caused an increased antidepressant effect compared to TRM and VEN administered alone, with no effect on locomotor activity or motor coordination in rats, which may be of clinical significance. It was also observed that reduced time of active swimming of animals in Porsolt test with an increased dose (10 and 20 mg/kg) and time of administration (7 and 14 days) of TRM were correlated with a decreased locomotor activity in rats. It may indicate the development of tolerance to TRM's antidepressant effect in rats during chronic treatment with doses higher than 5 mg/kg.

CONCLUSION

It can be expected that combination of low doses of TRM and VEN could potentially be feasible and relatively safe in cases with acute pain with co-existing depression, however, further investigations are needed.

摘要

背景

本研究旨在评估曲马多（TRM）和文拉法辛（VEN）联合给药在大鼠中的抗抑郁样作用（Porsolt 测试）、运动活性和运动协调。

方法

在单次和慢性（7 天和 14 天）腹腔内（ip）给予 TRM 和口服（po）给予 VEN 后，对雄性 Wistar 大鼠进行了这些测试。对照组给予 0.5%羧甲基纤维素（CMC）溶液（0.5 ml/只大鼠，ip 和 po）。

结果

发现与单独给予 TRM 和 VEN 相比，联合给予 TRM（5 mg/kg ip）和 VEN（20 mg/kg po）可增强抗抑郁作用，而对大鼠的运动活性或运动协调无影响，这可能具有临床意义。还观察到，随着 TRM 剂量（10 和 20 mg/kg）和给药时间（7 和 14 天）的增加，动物在 Porsolt 测试中主动游泳时间的减少与大鼠运动活性的降低有关。这可能表明在慢性治疗中，给予高于 5 mg/kg 的剂量时，大鼠对 TRM 的抗抑郁作用产生了耐受性。