Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, USA.
Retina. 2013 Apr;33(4):873-7. doi: 10.1097/IAE.0b013e31826d36dd.
To analyze the early spectral domain optical coherence tomography changes after fluocinolone implantation in eyes with baseline uveitic macular edema.
Patients with uveitic macular edema and who received fluocinolone implantations by 2 surgeons (R.P.S. and J.E.S.) at the Cole Eye Institute (Cleveland Clinic, Cleveland, OH) from September 2009 to July 2010 were eligible for this study. Best-corrected visual acuity, intraocular pressure, central subfield thickness, cube volume, cube average thickness, and cystoid macular edema grade were recorded before implantation and in the early postoperative period (median: 3 months postimplantation). Changes in these variables were analyzed using the Wilcoxon signed-rank test for paired comparisons of clustered data. P values were 2 sided, and alpha was set at 0.05.
Twelve eyes of seven patients were included in the study. The median best-corrected visual acuity improved in the early postoperative period after implantation (20/80 before implantation and 20/50 after implantation), but this improvement was not found to be significant (P = 0.12). However, the spectral domain optical coherence tomography measurements-central subfield thickness, cube volume, cube average thickness, and cystoid macular edema grade-were all significantly reduced (median changes: -234 μm [P = 0.02], -1 mm [P = 0.04], -39 μm [P = 0.04], and -3 [P = 0.03], respectively).
Fluocinolone implantation is associated with a significant reduction in macular edema as measured by spectral domain optical coherence tomography in the early postoperative period, a result that is consistent with the proposed mechanism of the drug.
分析基线葡萄膜炎性黄斑水肿患者氟轻松植入术后早期频域光相干断层扫描的变化。
本研究纳入了 2009 年 9 月至 2010 年 7 月期间在克利夫兰诊所Cole 眼研究所（克利夫兰，俄亥俄州）由两位外科医生（R.P.S.和 J.E.S.）进行氟轻松植入的葡萄膜炎性黄斑水肿患者。记录术前和术后早期（植入后中位 3 个月）的最佳矫正视力、眼内压、中央子场厚度、立方体积、立方平均厚度和囊样黄斑水肿分级。使用 Wilcoxon 符号秩检验对聚类数据的配对比较分析这些变量的变化。P 值为双侧，alpha 值设定为 0.05。
本研究共纳入了 7 名患者的 12 只眼。术后早期植入后最佳矫正视力有所改善（植入前为 20/80，植入后为 20/50），但差异无统计学意义（P = 0.12）。然而，频域光相干断层扫描测量的中央子场厚度、立方体积、立方平均厚度和囊样黄斑水肿分级均显著降低（中位数变化分别为-234 μm [P = 0.02]、-1 mm [P = 0.04]、-39 μm [P = 0.04]和-3 [P = 0.03]）。
频域光相干断层扫描显示，氟轻松植入术后早期黄斑水肿显著减轻，这与该药物的作用机制一致。
