Liu Han, Liu Ying, Xu Ying, Xue Yan
Departments of Intensive Care Unit, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, China.
Exp Ther Med. 2013 Mar;5(3):907-911. doi: 10.3892/etm.2013.884. Epub 2013 Jan 4.
The aim of this study was to evaluate the prognosis of patients following cardiopulmonary resuscitation in an intensive care unit (ICU) using bispectral index (BIS) monitoring. The study was a prospective comparative study performed at the academic department of an ICU. A total of 33 adults who received cardiopulmonary resuscitation were enrolled and divided into the surviving and non-surviving groups according to their 7-day survival status. During their stay in the ICU, the BIS and arterial oxygen saturation (SaO(2)) levels of all the patients were continuously monitored. The neurological condition of the patients was measured according to the Glasgow coma scale (GCS). Acute physiological and chronic diseases were measured according to the acute physiology and chronic health evaluation II (APACHE II). SaO(2) was monitored in all patients. The jugular bulb venous oxygen saturation (SjO(2)) levels were continuously monitored in 23 patients and the difference between the SaO(2) and SjO(2) values was used to indicate oxygen metabolism in the brain. The variables in the present study were compared between the 2 groups. The correlations between BIS values and GCS or APACHE II scores were analyzed. The BIS values were significantly higher in the surviving group than in the non-surviving group (P<0.01). The difference between the SaO(2) and SjO(2) was significant (P<0.01). There was a positive correlation between BIS values and GCS scores (r=0.821, P<0.01) and between BIS values and APACHE II scores (r=0.434, P<0.05). BIS values may be used to predict the post-resuscitative outcome of patients following cardiopulmonary resuscitation.
本研究旨在使用脑电双频指数（BIS）监测评估重症监护病房（ICU）中心肺复苏术后患者的预后。该研究是在一所大学附属医院的ICU学术科室进行的一项前瞻性对照研究。共有33例接受心肺复苏的成年患者入组，并根据其7天生存状态分为存活组和非存活组。在患者入住ICU期间，持续监测所有患者的BIS和动脉血氧饱和度（SaO₂）水平。根据格拉斯哥昏迷量表（GCS）评估患者的神经状况。根据急性生理与慢性健康状况评分系统II（APACHE II）评估急性生理状况和慢性疾病。监测所有患者的SaO₂。对23例患者持续监测颈静脉球部血氧饱和度（SjO₂）水平，并使用SaO₂与SjO₂值之间的差值来指示脑氧代谢情况。对本研究中的变量在两组之间进行比较。分析BIS值与GCS或APACHE II评分之间的相关性。存活组的BIS值显著高于非存活组（P<0.01）。SaO₂与SjO₂之间的差异具有统计学意义（P<0.01）。BIS值与GCS评分之间存在正相关（r=0.821，P<0.01），与APACHE II评分之间也存在正相关（r=0.434，P<0.05）。BIS值可用于预测心肺复苏术后患者的复苏后结局。
