Laboratory of Photochemistry and Spectroscopy, Division of Molecular Imaging and Photonics, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium.
Nanoscale. 2013 Mar 21;5(6):2264-8. doi: 10.1039/c3nr34231j.
We have used scanning force microscopy (SFM) to elucidate the dynamic behavior of open (torsionally unconstrained) circular and long linear DNA molecules during the relaxation process following adsorption onto mica. We find that bending stress and excluded volume effects drive the conformational equilibration via segmental out-of-plane dynamics.
我们利用扫描力显微镜(SFM)阐明了在吸附到云母上后,处于松弛过程中的开环(扭转不受约束)圆形和长线性 DNA 分子的动态行为。我们发现,弯曲应力和排除体积效应通过片段的出平面动力学驱动构象平衡。