Sumer Mahmut, Keles Gonca Cayir, Cetinkaya Burcu Ozkan, Balli Umut, Pamuk Ferda, Uckan Sina
Department of Oral Surgery, Faculty of Dentistry, Ondokuz Mayis University, Samsun, TURKIYE.
Eur J Dent. 2013 Jan;7(1):6-14.
The aim of this 6-month prospective randomized clinical study was to compare the effectiveness of autogenous cortical bone (ACB) and bioactive glass (BG) grafting for the regenerative treatment of intraosseous periodontal defects.
Via a split-mouth design, 15 chronic periodontitis patients (7 men, 8 women; mean age, 43.47 ± 1.45 years) who had probing pocket depths (PPDs) of ⩾6 mm following initial periodontal therapy were randomly assigned to receive 2 treatments in contralateral areas of the dentition: ACB grafting and BG grafting. The parameters compared in the patients were preoperative and 6-month postoperative PPDs, clinical attachment levels (CALs), and radiographic alveolar bone heights.
Both treatment modalities resulted in significant changes in postoperative measurements when compared to preoperative values (p < 0.01). PPDs were decreased, CALs were increased, and radiographic alveolar bone heights were increased by 5.00 ± 0.28, 4.60 ± 0.21, and 5.80 ± 0.43 mm in patients treated with ACB grafting and 5.13 ± 0.32, 4.67 ± 0.27, and 5.33 ± 0.36 mm in patients treated with BG grafting, respectively. Differences between the treatments were not statistically significant (P>.05).
Within the limitations of this study, both ACB and BG grafting led to significant improvements in clinical and radiographic parameters 6 months postoperatively. These results suggest that either an ACB graft, which is completely safe with no associated concerns about disease transmission and immunogenic reactions, or a BG graft, which has an unlimited supply, can be selected for regenerative periodontal treatment.
本为期6个月的前瞻性随机临床研究旨在比较自体皮质骨（ACB）移植和生物活性玻璃（BG）移植对骨内牙周缺损再生治疗的效果。
采用分口设计，将15例慢性牙周炎患者（7例男性，8例女性；平均年龄43.47±1.45岁），在初始牙周治疗后探诊袋深度（PPD）≥6mm，随机分配在牙列的对侧区域接受两种治疗：ACB移植和BG移植。比较患者术前和术后6个月的PPD、临床附着水平（CAL）和影像学牙槽骨高度等参数。
与术前值相比，两种治疗方式术后测量值均有显著变化（p<0.01）。ACB移植治疗的患者PPD降低，CAL增加，影像学牙槽骨高度增加5.00±0.28、4.60±0.21和5.80±0.43mm；BG移植治疗的患者分别为5.13±0.32、4.67±0.27和5.33±0.36mm。两种治疗之间的差异无统计学意义（P>0.05）。
在本研究的局限性内，ACB和BG移植术后6个月均导致临床和影像学参数显著改善。这些结果表明，对于牙周再生治疗，既可以选择完全安全且不存在疾病传播和免疫原性反应相关问题的ACB移植，也可以选择供应无限制的BG移植。
