Department of Cell Biology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
Mol Reprod Dev. 2013 Aug;80(8):665-76. doi: 10.1002/mrd.22161. Epub 2013 Mar 18.
The earliest stages of embryonic development in many animals proceed without zygotic transcription. Genetic control is executed by maternally inherited mRNAs that are under translational control. To set aside the future germ cell lineage, it is pivotal to both exert translational regulation of maternal germline mRNAs and to repress maternal signals in those same cells that drive somatic cell-fate determination. Here we review repressive translational regulation in the germline from the perspective of the conserved RNA binding proteins Pumilio and Nanos, and discuss common themes that have emerged.
在许多动物中，胚胎发育的最早阶段是在没有合子转录的情况下进行的。遗传控制是由母体遗传的 mRNA 执行的，这些 mRNA 受到翻译控制。为了确定未来的生殖细胞谱系，关键是对母体生殖系 mRNA 进行翻译调控，并抑制那些驱动体细胞命运决定的同一细胞中的母体信号。在这里，我们从保守的 RNA 结合蛋白 pumilio 和 nanos 的角度来回顾生殖系中的抑制性翻译调控，并讨论出现的共同主题。
