Kelly J G, Hunt S, Doyle G D, Laher M S, Carmody M, Marzo A, Arrigoni Martelli E
Institute of Biopharmaceutics, Athlone, Ireland.
Eur J Clin Pharmacol. 1990;38(3):309-12. doi: 10.1007/BF00315038.
Acetyl-L-carnitine 1.5 g and 3.0 g was administered as three divided doses on each of two occasions to 24 people with varying renal failure (creatinine clearance 127-8 ml.min-1). Plasma and urinary concentrations of total-L-carnitine, free (non-esterified) carnitine, short-chain esters and acetyl-L-carnitine were measured. The baseline (pre-study) concentrations of all four substances were related to renal function. Patients whose creatinine clearance was below about 30-40 ml.min-1 were had the highest concentrations. Renal elimination of all four substances was related to dose and to renal function. There was evidence for dose-related elimination, with greater elimination of the larger dose.
将1.5克和3.0克乙酰左旋肉碱分三次服用，在两个不同时间段分别给予24名不同程度肾衰竭（肌酐清除率为127 - 8毫升·分钟⁻¹）的患者。测量了血浆和尿液中总左旋肉碱、游离（非酯化）肉碱、短链酯和乙酰左旋肉碱的浓度。这四种物质的基线（研究前）浓度与肾功能有关。肌酐清除率低于约30 - 40毫升·分钟⁻¹的患者浓度最高。这四种物质的肾脏清除与剂量和肾功能有关。有证据表明存在剂量相关的清除，较大剂量的清除量更大。
