皮质5-羟色胺2受体异常调节的进一步证据：5-羟色胺前体的研究

Further evidence for an anomalous regulation of cortical 5-HT2 receptors: studies with 5-HT precursors.

作者信息

Koshikawa N, Koshikawa F, Stephenson J D

机构信息

Department of Pharmacology, Nihon University School of Dentistry, Tokyo, Japan.

出版信息

Eur J Pharmacol. 1990 Mar 27;178(3):365-9. doi: 10.1016/0014-2999(90)90116-n.

DOI:10.1016/0014-2999(90)90116-n

PMID:2340865

Abstract

Rats pretreated with either phenelzine (50 mg/kg 18 h and 12 mg/kg 90 min previously) or carbidopa (25 mg/kg 30 min previously) then given tryptophan or 5-hydroxytryptophan (5-HTP), developed wet-dog shakes which were more intense after 5-HTP. Cortical 5-HT2 receptors were significantly reduced within 3 h of tryptophan (150 or 500 mg/kg) given to phenelzine-treated rats. 5-HTP either did not affect (150 mg/kg) or slightly increased (350 mg/kg) 5-HT2 receptor numbers in rats pretreated with carbidopa. The response to 5-HTP (350 mg/kg) was not altered by pretreatment with alpha-methyl-p-tyrosine, haloperidol, propranolol or yohimbine.

摘要

先用苯乙肼（分别于18小时前给予50毫克/千克、90分钟前给予12毫克/千克）或卡比多巴（30分钟前给予25毫克/千克）预处理大鼠，然后给予色氨酸或5-羟色氨酸（5-HTP），大鼠会出现湿狗样颤抖，给予5-HTP后颤抖更剧烈。给用苯乙肼处理过的大鼠给予色氨酸（150或500毫克/千克）后3小时内，皮质5-HT2受体显著减少。在用卡比多巴预处理的大鼠中，5-HTP（150毫克/千克）对5-HT2受体数量无影响，（350毫克/千克）则使其略有增加。用α-甲基-对-酪氨酸、氟哌啶醇、普萘洛尔或育亨宾预处理不会改变对5-HTP（350毫克/千克）的反应。