从一家生产低酸罐装食品工厂用于冷却的水中分离出的肉毒梭菌菌株的基因组序列草图
Draft Genome Sequence of a Clostridium botulinum Isolate from Water Used for Cooling at a Plant Producing Low-Acid Canned Foods.
作者信息
Basavanna Uma, Gonzalez-Escalona Narjol, Timme Ruth, Datta Shomik, Schoen Brianna, Brown Eric W, Zink Donald, Sharma Shashi K
机构信息
Division of Microbiology, Office of Regulatory Science.
出版信息
Genome Announc. 2013 Jan;1(1). doi: 10.1128/genomeA.00200-12. Epub 2013 Feb 14.
Abstract
Clostridium botulinum is a pathogen of concern for low-acid canned foods. Here we report draft genomes of a neurotoxin-producing C. botulinum strain isolated from water samples used for cooling low-acid canned foods at a canning facility. The genome sequence confirmed that this strain belonged to C. botulinum serotype B1, albeit with major differences, including thousands of unique single nucleotide polymorphisms (SNPs) compared to other genomes of the same serotype.
摘要
肉毒梭菌是低酸罐装食品中令人担忧的一种病原体。在此，我们报告了从一家罐头厂用于冷却低酸罐装食品的水样中分离出的一株产神经毒素肉毒梭菌菌株的基因组草图。基因组序列证实该菌株属于肉毒梭菌B1型，不过存在一些主要差异，包括与同一血清型的其他基因组相比有数千个独特的单核苷酸多态性（SNP）。
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本文引用的文献
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Appl Environ Microbiol. 2010 Nov;76(22):7653-7. doi: 10.1128/AEM.00820-10. Epub 2010 Oct 1.
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Botulism in the United States: a clinical and epidemiologic review.美国的肉毒中毒：临床与流行病学综述
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Gene arrangement in the upstream region of Clostridium botulinum type E and Clostridium butyricum BL6340 progenitor toxin genes is different from that of other types.肉毒梭菌E型和丁酸梭菌BL6340祖毒素基因上游区域的基因排列与其他类型不同。
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