Bhatti Hamza, Khalid Nauman, Rao Babar
Nassau University Medical Center, East Meadow, New York, USA.
Cutis. 2012 Dec;90(6):297-9.
We report a case of superficial pyoderma gangrenosum (SPG) that was successfully treated with infliximab. A 22-year-old man presented with several polycyclic, purplish red plaques with some crusting and well-defined edges on the bilateral lower extremities. Histology showed superficial and deep mixed inflammatory cell infiltrate with prominent neutrophils and scarring noted as a result of multiple sinus tract formations that were characteristic of SPG. After unsuccessful results with typical treatments (ie, steroids, antibiotics, immunosuppressants), the patient was successfully treated with infliximab.
我们报告一例用英夫利昔单抗成功治疗的浅表性坏疽性脓皮病（SPG）。一名22岁男性双下肢出现数个多环状、紫红色斑块，有一些结痂，边缘清晰。组织学显示浅表和深部混合性炎性细胞浸润，中性粒细胞显著，由于多个窦道形成导致瘢痕形成，这是SPG的特征。在采用典型治疗方法（即类固醇、抗生素、免疫抑制剂）治疗效果不佳后，该患者用英夫利昔单抗成功治愈。
