犬下颌骨肉瘤的生物学行为。50例病例（1999 - 2007年）的回顾性研究。
Biological behaviour of canine mandibular osteosarcoma. A retrospective study of 50 cases (1999-2007).
作者信息
Coyle V J, Rassnick K M, Borst L B, Rodriguez C O, Northrup N C, Fan T M, Garrett L D
机构信息
College of Veterinary Medicine, University of Illinois, Urbana, IL, USA.
College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
出版信息
Vet Comp Oncol. 2015 Jun;13(2):89-97. doi: 10.1111/vco.12020. Epub 2013 Feb 15.
The purpose of this retrospective study was to describe the biological behaviour of canine mandibular osteosarcoma (OSA) and to examine factors for their impact on metastasis-free interval (MFI) and survival time (ST). Records from dogs treated with mandibulectomy for OSA (1999-2007) were reviewed. Archived tumour samples were evaluated for mitotic index (MI) and tumour grade. Fifty dogs were included, 21 received chemotherapy. Twenty-nine dogs (58%) developed metastatic disease. The median MFI was 627 days, and median ST was 525 days. In univariate analysis MI > 40 was prognostic for decreased MFI and ST. Grade also influenced MFI and ST, with 5/21 (24%) dogs with grade II/III tumours metastasis-free at one year versus 16/22 (72%) dogs with grade I tumours (P = 0.002); and 5/21 (24%) dogs with grade II/III tumours alive versus 17/22 (77%) dogs with grade I tumours (P = 0.001). In multivariate analysis, histological grade and adjuvant chemotherapy were prognostic for MFI and ST.
本回顾性研究的目的是描述犬下颌骨肉瘤（OSA）的生物学行为，并研究影响无转移生存期（MFI）和生存时间（ST）的因素。回顾了1999年至2007年接受下颌骨切除术治疗OSA的犬的记录。对存档的肿瘤样本进行有丝分裂指数（MI）和肿瘤分级评估。纳入50只犬，其中21只接受了化疗。29只犬（58%）发生了转移性疾病。中位MFI为627天，中位ST为525天。单因素分析中，MI>40提示MFI和ST降低。分级也影响MFI和ST，21只II/III级肿瘤犬中有5只（24%）在1年时无转移，而22只I级肿瘤犬中有16只（72%）无转移（P=0.002）；21只II/III级肿瘤犬中有5只（24%）存活，而22只I级肿瘤犬中有17只（77%）存活（P=0.001）。多因素分析中，组织学分级和辅助化疗对MFI和ST具有预后意义。
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