使用可乐定治疗共病 PTSD 和创伤性脑损伤患者的噩梦。
The use of clonidine in the treatment of nightmares among patients with co-morbid PTSD and traumatic brain injury.
机构信息
VA Medical Center, Syracuse, New York, USA.
出版信息
Int J Psychiatry Med. 2012;44(2):165-9. doi: 10.2190/PM.44.2.g.
OBJECTIVE
To describe the successful treatment of PTSD associated nightmares in two patients with PTSD.
CASE SUMMARIES
The report of the successful use of clonidine to treat PTSD associated nightmares among two Veterans following combat exposure.
DISCUSSION
Clonidine, a centrally acting alpha-agonist agent used to treat hypertension, stimulates alpha-adrenoreceptors in the brain stem. This action results in reduced sympathetic outflow from the central nervous system. We hypothesize that this central mechanism of action is why clonidine may be more effective in treating nightmares among patients with PTSD when compared with other agents.
CONCLUSION
Clonidine should be considered as an alternative in the treatment of nightmares among patients with PTSD.
目的
描述对 2 例创伤后应激障碍相关梦魇患者成功进行的治疗。
病例总结
本文报告了使用可乐定成功治疗 2 例经历过战斗暴露的退伍军人创伤后应激障碍相关梦魇。
讨论
可乐定是一种用于治疗高血压的中枢作用 α-激动剂，可刺激脑干中的α-肾上腺素能受体。该作用导致来自中枢神经系统的交感神经输出减少。我们假设，与其他药物相比，可乐定在治疗创伤后应激障碍患者的梦魇方面可能更有效，其作用机制是中枢机制。
结论
对于创伤后应激障碍患者的梦魇，应考虑将可乐定作为一种替代治疗药物。
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