Medical Readiness Systems Biology, Walter Reed Army Institute of Research, Silver Spring, Maryland.
Department of Sleep Medicine, Walter Reed National Military Medical Center, Bethesda, Maryland.
J Clin Sleep Med. 2022 Sep 1;18(9):2291-2312. doi: 10.5664/jcsm.10074.
Scientific evidence that acute, posttrauma sleep disturbances (eg, nightmares and insomnia) can contribute significantly to the pathogenesis of trauma-induced disorders is compelling. Sleep disturbances precipitating from trauma are uniquely predictive of daytime posttrauma symptom occurrence and severity, as well as subsequent onset of mental health disorders, including post-traumatic stress disorder. Conversely, adequate sleep during the acute posttrauma period is associated with reduced likelihood of adverse mental health outcomes. These findings, which are broadly consistent with what is known about the role of sleep in the regulation of emotion, suggest that the acute posttrauma period constitutes a "window of opportunity" during which treatment of sleep disturbances may be especially effective for preventing or mitigating progression of aberrant psychophysiological processes. At this point, the weight of the scientific evidence supporting this possibility warrants initiation of clinical trials to confirm the benefits of targeted prophylactic sleep enhancement, and to establish treatment guidelines as appropriate.
Swift KM, Thomas CL, Balkin TJ, Lowery-Gionta EG, Matson LM. Acute sleep interventions as an avenue for treatment of trauma-associated disorders. . 2022;18(9):2291-2312.
科学证据表明，急性创伤后睡眠障碍（如噩梦和失眠）可能对创伤引起的疾病的发病机制有重大影响。创伤引发的睡眠障碍可独特地预测日间创伤后症状的发生和严重程度，以及随后精神疾病的发作，包括创伤后应激障碍。相反，在急性创伤后期间有充足的睡眠与不良心理健康结果的可能性降低有关。这些发现与我们对睡眠在情绪调节中的作用的了解基本一致，这表明急性创伤后时期构成了一个“机会之窗”，在此期间，治疗睡眠障碍可能特别有效，可以预防或减轻异常心理生理过程的进展。在这一点上，支持这种可能性的科学证据的份量证明有必要启动临床试验，以确认有针对性的预防性睡眠增强的益处，并制定适当的治疗指南。
Swift KM、Thomas CL、Balkin TJ、Lowery-Gionta EG、Matson LM。急性睡眠干预作为治疗与创伤相关障碍的途径。 . 2022;18(9):2291-2312.
