Savk E, Uslu M, Yavaşoğlu I, Kadıköylü G, Sendur N, Karaman G
Adnan Menderes University, Department of Dermatology, Turkey.
Transfus Apher Sci. 2013 Apr;48(2):273-5. doi: 10.1016/j.transci.2013.01.008. Epub 2013 Feb 13.
Adjuvant therapeutic methods are employed when pemphigus vulgaris (PV) fails to be controlled by conventional corticosteroid treatment.
The efficacy of double filtration plasmapheresis (DFPP) was investigated in a PV patient with severe, refractory mucosal disease.
A total of 3 DFPP cycles, each cycle consisting of 5 double filtration sessions conducted on alternate days was completed.
DFPP provided immediate clinical relief of symptoms as well as a significant decrease in anti-desmoglein antibody levels and allowed for a much lower corticosteroid dose.
DFPP was an effective and safe adjuvant therapy in our patient with PV and it offers a valid treatment option in PV patients with recalcitrant disease.
当寻常型天疱疮（PV）无法通过传统皮质类固醇治疗得到控制时，会采用辅助治疗方法。
研究双重滤过血浆置换（DFPP）对一名患有严重难治性黏膜疾病的PV患者的疗效。
共完成3个DFPP疗程，每个疗程由5次隔日进行的双重滤过治疗组成。
DFPP使症状立即得到临床缓解，抗桥粒芯糖蛋白抗体水平显著降低，并使皮质类固醇剂量大幅降低。
DFPP对我们的PV患者是一种有效且安全的辅助治疗方法，为患有顽固性疾病的PV患者提供了一种有效的治疗选择。
