Nelson C V, Angelakos E T, Bonner R A, Hodgkin B C
Research Department, Maine Medical Center, Portland 04102.
J Electrocardiol. 1990 Apr;23(2):137-45. doi: 10.1016/0022-0736(90)90134-n.
Myocardial infarctions were produced in young domestic farm pigs by ligating coronary arteries. Arteries ligated in four groups were (A) left anterior descending, (B) branches of left anterior descending, (C) left circumflex, and (D) right coronary artery. After 7 or 8 days, the hearts were removed and dissected and the infarcted areas measured. Vectorcardiograms were taken before ligation and just before termination. High recording speeds and sensitivities were used so that details of the QRS complexes could be seen. Difference vectors were computed as a function of time during QRS. In groups A and B, statistically significant differences in QRS components before and after ligation were found. Also, there were statistically significant correlations between vectorcardiographic deflections and the ratio of infarct weight to heart weight. The changes were related to known excitation patterns of the pig heart.
通过结扎冠状动脉在幼年家猪身上制造心肌梗死。在四组中结扎的动脉分别为：（A）左前降支，（B）左前降支分支，（C）左旋支，以及（D）右冠状动脉。7或8天后，取出心脏并进行解剖，测量梗死面积。在结扎前和即将结束前记录向量心电图。使用高记录速度和灵敏度，以便能看到QRS复合波的细节。计算QRS期间作为时间函数的差值向量。在A组和B组中，发现结扎前后QRS成分存在统计学显著差异。此外，向量心电图偏转与梗死重量与心脏重量之比之间存在统计学显著相关性。这些变化与猪心脏已知的兴奋模式有关。
