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A new development in DNA repair modulation: discovery of a BLM helicase inhibitor.DNA修复调控的新进展：一种BLM解旋酶抑制剂的发现。
Cell Cycle. 2013 Mar 1;12(5):713-4. doi: 10.4161/cc.23953. Epub 2013 Feb 19.
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Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein.揭示人类布鲁姆综合征蛋白选择性抑制剂的别构作用模式。
Elife. 2021 Mar 1;10:e65339. doi: 10.7554/eLife.65339.
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A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.一种BLM解旋酶的小分子抑制剂可调节人类细胞中的染色体稳定性。
Chem Biol. 2013 Jan 24;20(1):55-62. doi: 10.1016/j.chembiol.2012.10.016.
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Discovery of Isaindigotone Derivatives as Novel Bloom's Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair.发现异吲哚二酮衍生物作为新型布鲁姆综合征蛋白（BLM）解旋酶抑制剂，可破坏 BLM/DNA 相互作用并调节同源重组修复。
J Med Chem. 2019 Mar 28;62(6):3147-3162. doi: 10.1021/acs.jmedchem.9b00083. Epub 2019 Mar 14.
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Small-Molecule Inhibitors Targeting DNA Repair and DNA Repair Deficiency in Research and Cancer Therapy.靶向 DNA 修复和 DNA 修复缺陷的小分子抑制剂在研究和癌症治疗中的应用。
Cell Chem Biol. 2017 Sep 21;24(9):1101-1119. doi: 10.1016/j.chembiol.2017.08.027.
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Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress.小分子抑制解旋酶活性会损害沃纳综合征解旋酶（WRN）在细胞应对 DNA 损伤或复制应激中的功能。
Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1525-30. doi: 10.1073/pnas.1006423108. Epub 2011 Jan 10.
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Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA.与ADP和双链DNA结合的人类布卢姆综合征解旋酶的结构。
Acta Crystallogr D Biol Crystallogr. 2014 May;70(Pt 5):1465-75. doi: 10.1107/S139900471400501X. Epub 2014 Apr 30.
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Inhibition of DNA helicase, ATPase and DNA-binding activities of E. coli RecQ helicase by chemotherapeutic agents.化疗药物对大肠杆菌RecQ解旋酶的DNA解旋酶活性、ATP酶活性及DNA结合活性的抑制作用。
J Biochem. 2008 Jun;143(6):773-9. doi: 10.1093/jb/mvn026. Epub 2008 Feb 22.
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Differential and Concordant Roles for Poly(ADP-Ribose) Polymerase 1 and Poly(ADP-Ribose) in Regulating WRN and RECQL5 Activities.聚（ADP-核糖）聚合酶1和聚（ADP-核糖）在调节WRN和RECQL5活性中的差异作用与协同作用
Mol Cell Biol. 2015 Dec;35(23):3974-89. doi: 10.1128/MCB.00427-15. Epub 2015 Sep 21.
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Central role for the Werner syndrome protein/poly(ADP-ribose) polymerase 1 complex in the poly(ADP-ribosyl)ation pathway after DNA damage.沃纳综合征蛋白/聚（ADP - 核糖）聚合酶1复合物在DNA损伤后聚（ADP - 核糖基）化途径中的核心作用。
Mol Cell Biol. 2003 Dec;23(23):8601-13. doi: 10.1128/MCB.23.23.8601-8613.2003.
引用本文的文献
1
Screening antiproliferative drug for breast cancer from bisbenzylisoquinoline alkaloid tetrandrine and fangchinoline derivatives by targeting BLM helicase.以 BLM 解旋酶为靶点从双苄基异喹啉生物碱汉防己甲素和粉防己碱衍生物中筛选乳腺癌增殖抑制剂。
BMC Cancer. 2019 Oct 28;19(1):1009. doi: 10.1186/s12885-019-6146-7.
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Werner Syndrome Helicase Is Required for the Survival of Cancer Cells with Microsatellite Instability.微卫星不稳定的癌细胞存活需要沃纳综合征解旋酶
iScience. 2019 Mar 29;13:488-497. doi: 10.1016/j.isci.2019.02.006. Epub 2019 Mar 18.
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Clinicopathological and Functional Significance of RECQL1 Helicase in Sporadic Breast Cancers.RECQL1解旋酶在散发性乳腺癌中的临床病理及功能意义
Mol Cancer Ther. 2017 Jan;16(1):239-250. doi: 10.1158/1535-7163.MCT-16-0290. Epub 2016 Nov 11.
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RECQL1 and WRN DNA repair helicases: potential therapeutic targets and proliferative markers against cancers.RECQL1和WRN DNA修复解旋酶：针对癌症的潜在治疗靶点和增殖标志物。
Front Genet. 2015 Jan 9;5:441. doi: 10.3389/fgene.2014.00441. eCollection 2014.
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A hidden role of the inactivated FANCD2: upregulating ΔNp63.失活的FANCD2的一个潜在作用：上调ΔNp63。
Oncotarget. 2013 Sep;4(9):1416-26. doi: 10.18632/oncotarget.1217.
本文引用的文献
1
A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.一种BLM解旋酶的小分子抑制剂可调节人类细胞中的染色体稳定性。
Chem Biol. 2013 Jan 24;20(1):55-62. doi: 10.1016/j.chembiol.2012.10.016.
2
An inhibitor of nonhomologous end-joining abrogates double-strand break repair and impedes cancer progression.一种非同源末端连接抑制剂可阻断双链断裂修复并阻碍癌症进展。
Cell. 2012 Dec 21;151(7):1474-87. doi: 10.1016/j.cell.2012.11.054.
3
Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors.临床 PARP 抑制剂对 PARP1 和 PARP2 的捕获。
Cancer Res. 2012 Nov 1;72(21):5588-99. doi: 10.1158/0008-5472.CAN-12-2753.
4
Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress.小分子抑制解旋酶活性会损害沃纳综合征解旋酶（WRN）在细胞应对 DNA 损伤或复制应激中的功能。
Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1525-30. doi: 10.1073/pnas.1006423108. Epub 2011 Jan 10.
5
Homologous recombination in cancer development, treatment and development of drug resistance.同源重组在癌症发展、治疗和耐药性发展中的作用。
Carcinogenesis. 2010 Jun;31(6):955-60. doi: 10.1093/carcin/bgq064. Epub 2010 Mar 29.
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RecQ helicases: multifunctional genome caretakers.RecQ解旋酶：多功能的基因组守护者。
Nat Rev Cancer. 2009 Sep;9(9):644-54. doi: 10.1038/nrc2682. Epub 2009 Aug 6.
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Syndrome-causing mutations of the BLM gene in persons in the Bloom's Syndrome Registry.布卢姆综合征登记处人群中BLM基因的致综合征突变。
Hum Mutat. 2007 Aug;28(8):743-53. doi: 10.1002/humu.20501.
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The Bloom's syndrome gene product is homologous to RecQ helicases.布卢姆氏综合征基因产物与RecQ解旋酶同源。
Cell. 1995 Nov 17;83(4):655-66. doi: 10.1016/0092-8674(95)90105-1.
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