Krueger G R, Graw R G, Rogentine G N, Darrow C C, Neefe J R, Luetzeler J
Blut. 1975 Jan;30(1):19-30. doi: 10.1007/BF01633783.
Lethally irradiated rhesus monkeys were used for bone marrow allografting and autografting. Monkeys receiving allogeneic bone marrow developed acute graft-versus-host reaction (GVHR) and had a mean survival time of 9.1 days as compared to autografted monkeys which survived above 500 days. Treatment with antilymphocyte sera (ALS) before allografting modified the GVHR and extended the survival time to an average of 43 days. Histologically, such animals showed evidence of "chronic" GVHR and septicemia secondary to a lack in lymphoreticular recovery. Subsequently, severe GI-tract infections followed which usually served as portal of entry for septicemia.
致死剂量照射的恒河猴用于骨髓同种异体移植和自体移植。接受同种异体骨髓的猴子发生了急性移植物抗宿主反应（GVHR），平均存活时间为9.1天，而自体移植的猴子存活时间超过500天。同种异体移植前用抗淋巴细胞血清（ALS）治疗可改变GVHR，并将存活时间延长至平均43天。组织学上，这些动物表现出“慢性”GVHR和继发于淋巴网状组织恢复不足的败血症的证据。随后，严重的胃肠道感染接踵而至，这些感染通常是败血症的入口。
