脂质积聚产物与多囊卵巢综合征女性的代谢综合征有关。
Lipid accumulation product is related to metabolic syndrome in women with polycystic ovary syndrome.
作者信息
Xiang S, Hua F, Chen L, Tang Y, Jiang X, Liu Z
机构信息
Department of Endocrinology, the Third Affiliated Hospital of Suzhou University, Changzhou, Jiangsu, China.
出版信息
Exp Clin Endocrinol Diabetes. 2013 Feb;121(2):115-8. doi: 10.1055/s-0032-1333261. Epub 2013 Feb 20.
PURPOSE
Metabolic disturbances are common features of polycystic ovary syndrome (PCOS), which possibly enhance the risk of diabetes and cardiovascular disease. Lipid accumulation product (LAP) is an emerging cardiovascular risk factor. The aim of this study was to explore the ability of LAP to identify metabolic syndrome (MS) in PCOS women.
METHODS
In a cross-sectional study, anthropometric, biochemical and clinical parameters were measured in 105 PCOS women. Receiver operating characteristic (ROC) analysis was used to find out the cut-off points of LAP to predict MS. MS was categorized according to International Diabetes Federation (IDF) criteria.
RESULTS
The prevalence of MS was 43.8% in this study. PCOS women with MS had significantly higher LAP levels compared to those without MS. LAP was highly correlated with components of MS. ROC analysis showed that LAP was a significant discriminator for MS in PCOS women, and the optimal cutoff point of LAP to predict MS was 54.2 (93.3% sensitivity, 96.7% specificity).
CONCLUSIONS
LAP seems to be associated with MS and has a strong and reliable diagnostic accuracy for MS in PCOS women.
目的
代谢紊乱是多囊卵巢综合征（PCOS）的常见特征，这可能会增加患糖尿病和心血管疾病的风险。脂质蓄积产物（LAP）是一种新出现的心血管危险因素。本研究旨在探讨LAP识别PCOS女性代谢综合征（MS）的能力。
方法
在一项横断面研究中，对105名PCOS女性进行了人体测量、生化和临床参数检测。采用受试者工作特征（ROC）分析来确定LAP预测MS的切点。MS根据国际糖尿病联盟（IDF）标准进行分类。
结果
本研究中MS的患病率为43.8%。患有MS的PCOS女性的LAP水平显著高于未患MS的女性。LAP与MS的各组分高度相关。ROC分析表明，LAP是PCOS女性MS的重要判别指标，预测MS的LAP最佳切点为54.2（灵敏度93.3%，特异度96.7%）。
结论
LAP似乎与MS相关，并且对PCOS女性的MS具有强大且可靠的诊断准确性。
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