Seyedi Seyed Arsalan, Nabipoorashrafi Seyed Ali, Amin Afshari Samira, Mansouri Afsoun, Alizadegan Dorsa, Hobaby Sara, Esmaeilpur Abianeh Fatemeh, Mechanick Jeffrey I, Esteghamati Alireza
Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Imam Khomeini Hospital, Tehran, Iran.
School of Pharmacy and Pharmaceutical Sciences, Islamic Azad University of Tehran Medical Sciences, Tehran, Iran.
Endocrinol Diabetes Metab. 2025 Sep;8(5):e70078. doi: 10.1002/edm2.70078.
Lipid accumulation product (LAP) index is a measure of lipid toxicity based on triglyceride and waist circumference. The aim of the current study is to explore the relationship between LAP index and metabolic syndrome (MetS) among women with polycystic ovary syndrome (PCOS) in a systematic review and meta-analysis.
Web of Science, Embase and PubMed online databases were systematically searched for studies investigating the relationship between LAP index and MetS in PCOS. Ten observational studies, including 12 populations with 2957 individuals, were identified for analysis. Mean difference and bivariate diagnostic test accuracy (DTA) meta-analyses were performed.
A significant LAP index difference of 49.17 was found in women with PCOS with and without MetS (95% CI [40.57, 57.77]). By DTA meta-analysis, the pooled sensitivity and specificity of LAP index for MetS detection were 87% (I 78%, 95% CI [80%, 92%]) and 88% (I 78%, 95% CI [83%, 92%]), respectively, with area under the curve of 0.94 (95% CI [0.91, 0.96]).
The LAP index is an affordable, specific and sensitive marker for MetS and may be considered a pragmatic tool for MetS detection among patients with PCOS, particularly those with an insulin resistance endotype.
脂质蓄积产物（LAP）指数是一种基于甘油三酯和腰围的脂质毒性测量指标。本研究的目的是通过系统评价和荟萃分析，探讨多囊卵巢综合征（PCOS）女性中LAP指数与代谢综合征（MetS）之间的关系。
系统检索Web of Science、Embase和PubMed在线数据库，查找关于PCOS中LAP指数与MetS关系的研究。共纳入10项观察性研究，包括12个群体的2957名个体进行分析。进行了平均差和双变量诊断试验准确性（DTA）荟萃分析。
患有和未患有MetS的PCOS女性的LAP指数存在显著差异，差值为49.17（95%可信区间[40.57, 57.77]）。通过DTA荟萃分析，LAP指数检测MetS的合并敏感性和特异性分别为87%（I² 78%，95%可信区间[80%, 92%]）和88%（I² 78%，95%可信区间[83%, 92%]），曲线下面积为0.94（95%可信区间[0.91, 0.96]）。
LAP指数是一种经济实惠、特异且敏感的MetS标志物，可被视为PCOS患者中检测MetS的实用工具，尤其是那些具有胰岛素抵抗内型的患者。
