Black I B, Reis D J
Brain Res. 1975 Feb 7;84(2):269-78. doi: 10.1016/0006-8993(75)90981-6.
The ontogeny of the induction of tyrosine hydroxylase by reserpine has been studied in the superior cervical ganglion, adrenal gland and nucleus locus coeruleus of the rat. The inductive response developed gradually over a period of days in all 3 areas. However, the onset of induction occurred at markedly different times in these regions, being present from day 2 of life, the earilest time tested, in the adrenal, day 6 in the locus coeruleus and day 24 in the ganglion. In the ganglion even extremely high, toxic doses of reserpine failed to induce the enzyme during the first 3 weeks of life. Decentralization studies indicated that the ganglion was functionally innervated at this time. Moreover, the onset of induction was not time-locked to a specific phase of the postnatal development of tyrosine hydroxylase activity in the areas examined. It is probable that the development of inducibility reflects maturation of mechanisms intrinsic to the adrenergic cell, and this timetable is different for cells in different areas.
利血平诱导酪氨酸羟化酶的个体发生已在大鼠的颈上神经节、肾上腺和蓝斑核中进行了研究。在所有这三个区域，诱导反应在数天的时间内逐渐发展。然而，诱导的起始时间在这些区域明显不同，在肾上腺中从出生后第2天（测试的最早时间）开始出现，在蓝斑核中为第6天，在神经节中为第24天。在神经节中，即使给予极高的、有毒剂量的利血平，在出生后的前三周内也未能诱导该酶。去神经支配研究表明，此时神经节已被功能性地支配。此外，诱导的起始时间与所检查区域中酪氨酸羟化酶活性的出生后发育的特定阶段没有时间关联。诱导性的发展可能反映了肾上腺素能细胞内在机制的成熟，并且这个时间表在不同区域的细胞中是不同的。
