Badley B W
Can Med Assoc J. 1975 Jan 25;112(2):200-4, 206.
Among drugs recently introduced into Canada for treatment of gastrointestinal disease are carbenoxolone sodium (used in treating gastric ulcer) and metoclopramide hydrochloride (which modifies upper gastrointestinal tract motility). A third drug, lactulose (useful in treating hepatic encephalopathy), will soon be available. Clinical experience with these drugs has been most extensive in Europe. In a new class of agents are histamine H2-receptor antagonists, which are currently under clinical trial. These drugs are the most potent inhibitors of gastric acid secretion yet investigated, and are potentially the most exciting agents to appear in many years. Part I of this paper is a review of the actions, clinical use, side effects, and dosage and administration of these new drugs.
最近引入加拿大用于治疗胃肠疾病的药物包括甘珀酸钠（用于治疗胃溃疡）和盐酸甲氧氯普胺（可调节上消化道动力）。第三种药物乳果糖（对治疗肝性脑病有用）很快也将上市。欧洲对这些药物的临床经验最为丰富。组胺H2受体拮抗剂是一类新型药物，目前正在进行临床试验。这些药物是迄今为止所研究的最有效的胃酸分泌抑制剂，可能是多年来出现的最令人兴奋的药物。本文的第一部分是对这些新药的作用、临床应用、副作用以及剂量和用法的综述。
