Curran C F, Luce J K, Page J A
Oncol Nurs Forum. 1990 May-Jun;17(3):387-9.
An analysis was made of 539 cases of venous flare reactions associated with the administration of doxorubicin. These reactions always were nondebilitating and generally were transient with complete resolution occurring within 45 minutes of onset in 462 patients (86%). Local urticaria occurred in 133 patients (25%), and 35 patients (6%) reported either vein pain or a stinging sensation. In 20 cases (4%), erythema in the region immediately surrounding the infusion site accompanied the primary manifestation of erythema along the course of the vein proximal to the infusion site. The incidence of initial flare reactions peaked in the autumn months. These reactions frequently occurred at clinical sites in sporadic clusters. Clinical features are described that differentiate flare reactions from early extravasations of doxorubicin. Procedures for minimizing the possibility of the occurrence or reappearance of flare reactions are suggested.
对539例与多柔比星给药相关的静脉发红反应进行了分析。这些反应通常并不使人衰弱，一般为短暂性，462例患者（86%）在发作后45分钟内完全消退。133例患者（25%）出现局部荨麻疹，35例患者（6%）报告有静脉疼痛或刺痛感。20例患者（4%）在输注部位周围区域出现红斑，同时沿输注部位近端静脉出现原发性红斑。初始发红反应的发生率在秋季月份达到峰值。这些反应经常在临床场所呈散发性聚集出现。描述了将发红反应与多柔比星早期外渗相鉴别的临床特征。提出了将发红反应发生或再次出现的可能性降至最低的程序。
