Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
World J Gastroenterol. 2013 Feb 14;19(6):964-7. doi: 10.3748/wjg.v19.i6.964.
Emergency ABO-incompatible (ABO-I) liver transplantations (LTx) have been performed increasingly to treat severe liver failure. Herein, we report a case of severe hepatic necrosis after ABO-I LTx. A 53-year-old man with blood group O was diagnosed as having severe hepatitis B and acute-on-chronic liver failure, and underwent an emergency liver transplantation implanting a blood-group-B liver from a cardiac-death donor. A routine anti-rejection, anti-infection and anti-virus therapy was given after operation. On post-operative day (POD) 16, the recipient had fever and erythra. Laboratory and radiographic examinations suggested a severe hepatic necrosis of unknown causes. The patient was managed with a 10-d methylprednisolone pulse therapy. He was discharged on POD 35 with stable condition, and no recurrent disease was found during the follow-up.
紧急 ABO 不相容（ABO-I）肝移植（LTx）已越来越多地用于治疗严重肝功能衰竭。在此，我们报告了一例 ABO-I LTx 后发生严重肝坏死的病例。一名 53 岁男性，血型为 O，被诊断为患有严重乙型肝炎和慢加急性肝衰竭，并接受了来自心脏死亡供体的血型为 B 的肝脏进行紧急肝移植。术后给予常规抗排斥、抗感染和抗病毒治疗。术后第 16 天，受者出现发热和红斑。实验室和影像学检查提示原因不明的严重肝坏死。患者接受了 10 天甲泼尼龙冲击治疗。他在术后第 35 天出院，病情稳定，随访期间未发现疾病复发。
