中药治疗骨质疏松症：随机对照试验的系统评价。

Chinese herbal medicine for osteoporosis: a systematic review of randomized controlled trails.

机构信息

Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 725 South Wanping Road, Shanghai 200032, China.

出版信息

Evid Based Complement Alternat Med. 2013;2013:356260. doi: 10.1155/2013/356260. Epub 2013 Jan 30.

Background. Osteoporosis is a major health problem for the elderly population. Chinese herb may be beneficial to osteoporosis due to its capability. Objectives. This study was designed to evaluate the effectiveness of Chinese medicine treatment on the patients with osteoporosis. Search Methods. Randomized controlled trials were retrieved from different 9 databases. Results. This meta analysis included 12 RCTs involving 1816 patients to compare Chinese herbs with placebo or standard anti-osteoporotic therapy in the treatment of bone loss. The pooled data showed that the percent change of increased BMD in the spine is higher with Chinese herb compared to placebo (lumber spine: WMD = 0.07, 95% CI: 0.01-0.04). In the femoral, Chinese herb showed significantly higher increments of BMD compared to placebo (femoral neck: WMD = 0.06, 95% CI: -0.02-0.13). Compared to the other standard anti-osteoporotic drugs, Chinese herbs also show advantage in BMD change (lumber spine: WMD = 0.03, 95% CI: -0.01-0.08; femoral: WMD = 0.01, 95% CI: -0.01-0.02). Conclusions. Our results demonstrated that Chinese herb significantly increased lumbar spine BMD as compared to the placebo or other standard anti-osteoporotic drugs.

背景

骨质疏松症是老年人群体的一个主要健康问题。中药可能因其功效而对骨质疏松症有益。

目的

本研究旨在评估中药治疗骨质疏松症患者的效果。

检索方法

从 9 个不同的数据库中检索随机对照试验。

结果

这项荟萃分析纳入了 12 项 RCT，涉及 1816 名患者，比较了中药与安慰剂或标准抗骨质疏松治疗在治疗骨质流失方面的疗效。汇总数据显示，与安慰剂相比，中药治疗组的脊柱骨密度增加百分比更高（腰椎：WMD=0.07，95%CI：0.01-0.04）。在股骨部位，与安慰剂相比，中药组的骨密度增加幅度明显更高（股骨颈：WMD=0.06，95%CI：-0.02-0.13）。与其他标准抗骨质疏松药物相比，中药在骨密度变化方面也具有优势（腰椎：WMD=0.03，95%CI：-0.01-0.08；股骨：WMD=0.01，95%CI：-0.01-0.02）。