Meurman J H, Porko C, Murtomaa H
Department of Cariology, University of Helsinki, Finland.
Scand J Dent Res. 1990 Apr;98(2):167-72. doi: 10.1111/j.1600-0722.1990.tb00956.x.
All patients who during the academic year 1987-88 had come or were referred for investigation to the Institute of Dentistry, University of Oulu, because of their anticipated amalgam-related symptoms were included in the study. The group comprised 20 patients, 7 men and 13 women, 41.6 +/- 11.1 yr old. For paired controls, 20 age and sex matched subjects were randomly selected among other patients at the Institute. The subjects' medical and dental history was taken, they were all examined clinically, and saliva analyses were done. The subjects were tested with standard patch test series of 25 common dental allergens. All patients were given the possibility to give a blood test for mercury concentration analysis, but only five were willing to do so. The results showed that the group of 20 patients suffered significantly more often from medical illnesses than the controls (P less than 0.05). Chronic craniofacial pain was diagnosed significantly more often among the patients than in the controls (P less than 0.01). The controls had more caries than the patients, but there was no difference in any other clinical, salivary chemical or microbiological findings between the groups. In the five patients who gave blood samples, both inorganic and organic mercury levels were below threshold values. No difference was observed between the patients and controls in the allergy test reactions.
所有在1987 - 1988学年期间因预期的汞合金相关症状前来或被转介到奥卢大学牙科学院进行检查的患者都被纳入该研究。该组包括20名患者，7名男性和13名女性，年龄为41.6 +/- 11.1岁。作为配对对照，在该学院的其他患者中随机挑选了20名年龄和性别匹配的受试者。记录了受试者的病史和牙科病史，对他们进行了临床检查，并进行了唾液分析。用25种常见牙科过敏原的标准斑贴试验系列对受试者进行检测。所有患者都有机会进行血液汞浓度分析检测，但只有5人愿意这样做。结果显示，20名患者组比对照组更频繁地患有内科疾病（P < 0.05）。患者中慢性颅面疼痛的诊断明显比对照组更频繁（P < 0.01）。对照组的龋齿比患者多，但两组在任何其他临床、唾液化学或微生物学检查结果上没有差异。在提供血样的5名患者中，无机汞和有机汞水平均低于阈值。在过敏试验反应中，患者和对照组之间未观察到差异。
