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科威特儿童肝脏移植在国外进行时出现的并发症。

Complications in paediatric liver transplant from Kuwait when transplanted abroad.

作者信息

Al-Khalidi Jameela A S J, Alenezi Bader, Al-Qabandy Wafa, Abo-Hamra Eman, Husain Khalid, Askar Haifa A, Jagannathan Ayyampalayam P, Abu-El-Naga Hisham, Neff Guy W

机构信息

Thuniyan Al-Ghanim, GI Center & University of Kuwait, Kuwait.

出版信息

Arab J Gastroenterol. 2012 Dec;13(4):178-9. doi: 10.1016/j.ajg.2012.08.011. Epub 2013 Jan 10.

DOI:10.1016/j.ajg.2012.08.011
PMID:23432986
Abstract

BACKGROUND AND STUDY AIMS

Since the introduction of liver transplantation (LTx) in children suffering from liver failure in 1963, many centres around the world have offered this service to children that have no other alternative. The aim of this retrospective study is to analyse the results of paediatric liver transplant in Kuwait over the last decade.

PATIENTS AND METHODS

A retrospective chart review was done involving paediatric patients during the time period of 1995-2004. The information collected included patient demographics, indications for liver transplantation, survival of both patient and allograft, and complications.

RESULTS

A total of 16 cases were found and analysed. The mean age was 3.6years (ranged 5months-17years). There were nine boys and seven girls. The most common indications for LTx were biliary atresia and metabolic liver disease. All the liver transplants were done abroad. There were totally nine deceased donor and seven living related cases. The complications were acute cellular rejection in five, hypertension in two, biliary complications in four, cytomegalovirus (CMV) infection in three and post lymphoproliferative disease in two cases. All but one patient are presently alive.

CONCLUSION

The above information demonstrates that LTx in Kuwati children is safe and improves the quality of life for those that would otherwise have no other alternative.

摘要

背景与研究目的

自1963年为肝功能衰竭儿童引入肝移植(LTx)以来,世界上许多中心都为别无选择的儿童提供这项服务。这项回顾性研究的目的是分析科威特过去十年小儿肝移植的结果。

患者与方法

对1995年至2004年期间的儿科患者进行回顾性病历审查。收集的信息包括患者人口统计学资料、肝移植指征、患者及移植物的存活情况以及并发症。

结果

共发现并分析了16例病例。平均年龄为3.6岁(范围为5个月至17岁)。有9名男孩和7名女孩。肝移植最常见的指征是胆道闭锁和代谢性肝病。所有肝移植均在国外进行。共有9例尸体供体病例和7例活体亲属供体病例。并发症包括5例急性细胞排斥反应、2例高血压、4例胆道并发症、3例巨细胞病毒(CMV)感染和2例淋巴增殖性疾病。除1例患者外,其他患者目前均存活。

结论

上述信息表明,科威特儿童肝移植是安全的,改善了那些别无选择的儿童的生活质量。

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