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本文引用的文献

1
Discordance between preoperative and postoperative bladder cancer location: implications for partial-bladder radiation.术前和术后膀胱癌位置的不一致：对部分膀胱放射治疗的影响。
Int J Radiat Oncol Biol Phys. 2013 Mar 1;85(3):707-13. doi: 10.1016/j.ijrobp.2012.05.022. Epub 2012 Jul 3.
2
Caveolin-1 upregulation contributes to c-Myc-induced high-grade prostatic intraepithelial neoplasia and prostate cancer.窖蛋白-1 的上调促进了 c-Myc 诱导的高级别前列腺上皮内瘤变和前列腺癌。
Mol Cancer Res. 2012 Feb;10(2):218-29. doi: 10.1158/1541-7786.MCR-11-0451. Epub 2011 Dec 5.
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GLIPR1 suppresses prostate cancer development through targeted oncoprotein destruction.GLIPR1 通过靶向癌蛋白破坏抑制前列腺癌的发展。
Cancer Res. 2011 Dec 15;71(24):7694-704. doi: 10.1158/0008-5472.CAN-11-1714. Epub 2011 Oct 24.
4
GLIPR1 tumor suppressor gene expressed by adenoviral vector as neoadjuvant intraprostatic injection for localized intermediate or high-risk prostate cancer preceding radical prostatectomy.腺病毒载体表达 GLIPR1 肿瘤抑制基因作为新辅助性前列腺内注射用于根治性前列腺切除术前局限性中高危前列腺癌。
Clin Cancer Res. 2011 Nov 15;17(22):7174-82. doi: 10.1158/1078-0432.CCR-11-1899. Epub 2011 Sep 20.
5
Tumor growth and metastasis suppression by Glipr1 gene-modified macrophages in a metastatic prostate cancer model.Glipr1 基因修饰的巨噬细胞抑制转移性前列腺癌模型中的肿瘤生长和转移。
Gene Ther. 2011 Oct;18(10):969-78. doi: 10.1038/gt.2011.51. Epub 2011 Apr 21.
6
The alkylphospholipid, perifosine, radiosensitizes prostate cancer cells both in vitro and in vivo.烷基磷酸脂质，培非司亭，在体外和体内均能增强前列腺癌细胞的放射敏感性。
Radiat Oncol. 2011 Apr 15;6:39. doi: 10.1186/1748-717X-6-39.
7
The CAP superfamily: cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins--roles in reproduction, cancer, and immune defense.CAP超家族：富含半胱氨酸的分泌蛋白、抗原5和病程相关蛋白1——在生殖、癌症和免疫防御中的作用
Endocr Rev. 2008 Dec;29(7):865-97. doi: 10.1210/er.2008-0032. Epub 2008 Sep 29.
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Glioma pathogenesis-related protein 1 exerts tumor suppressor activities through proapoptotic reactive oxygen species-c-Jun-NH2 kinase signaling.胶质瘤发病机制相关蛋白1通过促凋亡活性氧-c-Jun氨基末端激酶信号传导发挥肿瘤抑制作用。
Cancer Res. 2008 Jan 15;68(2):434-43. doi: 10.1158/0008-5472.CAN-07-2931.
9
Cooperative effects of adenoviral vector-mediated interleukin 12 gene therapy with radiotherapy in a preclinical model of metastatic prostate cancer.腺病毒载体介导的白细胞介素12基因治疗与放疗在转移性前列腺癌临床前模型中的协同作用。
Gene Ther. 2007 Feb;14(3):227-36. doi: 10.1038/sj.gt.3302788. Epub 2006 Oct 5.
10
Adenoviral vector-mediated RTVP-1 gene-modified tumor cell-based vaccine suppresses the development of experimental prostate cancer.腺病毒载体介导的基于RTVP-1基因修饰肿瘤细胞的疫苗可抑制实验性前列腺癌的发展。
Cancer Gene Ther. 2006 Jul;13(7):658-63. doi: 10.1038/sj.cgt.7700919. Epub 2006 Feb 17.

腺病毒载体介导的GLIPR1基因治疗与放射治疗在前列腺癌和膀胱癌模型中的联合治疗效果

Combined therapeutic effects of adenoviral vector-mediated GLIPR1 gene therapy and radiotherapy in prostate and bladder cancer models.

作者信息

Fujita Tetsuo, Satoh Takefumi, Timme Terry L, Hirayama Takahiro, Zhu Julie X, Kusaka Nobuyuki, Naruishi Koji, Yang Guang, Goltsov Alexei, Wang Jianxiang, Vlachaki Maria T, Teh Bin S, Brian Butler E, Thompson Timothy C

机构信息

Scott Department of Urology, Baylor College of Medicine, Houston, TX.

Scott Department of Urology, Baylor College of Medicine, Houston, TX; Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX.

出版信息

Urol Oncol. 2014 Feb;32(2):92-100. doi: 10.1016/j.urolonc.2012.10.007. Epub 2013 Feb 20.

DOI:10.1016/j.urolonc.2012.10.007
PMID:23433894
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3871954/
Abstract

OBJECTIVES

The objectives of this study are to explore the potential benefits of combining AdGlipr1 (or AdGLIPR1) gene therapy with radiotherapy using subcutaneous prostate and bladder cancer models.

MATERIALS AND METHODS

Combination adenoviral vector-mediated gene therapy and radiotherapy were applied to 178-2 BMA and TSU-Pr1 cells in vitro and colony formation and apoptosis were analyzed. In addition, combination therapies were administered to mice bearing subcutaneous 178-2 BMA and TSU-Pr1 tumors, and tumor growth suppression and survival extension were compared with the monotherapies (AdGlipr1/AdGLIPR1 and radiotherapy) or control vector Adv/CMV/βgal, as well as single-cycle treatment with 2-cycle treatment.

RESULTS

Combination treatment significantly suppressed colony formation and increased apoptosis in vitro. In vivo, combination therapy produced significant 178-2 BMA and TSU-Pr1 tumor growth suppression and survival extension compared with the monotherapies or the control. Further tumor growth suppression and survival extension were observed after 2 cycles of the combination treatment.

CONCLUSIONS

Combining AdGlipr1 (AdGLIPR1) with radiotherapy may achieve additive or synergistic tumor control in selected prostate and bladder tumors, and additional therapeutic effects may result with repeated treatment cycles.

摘要

目的

本研究的目的是利用皮下前列腺癌和膀胱癌模型探索联合AdGlipr1（或AdGLIPR1）基因治疗与放射治疗的潜在益处。

材料与方法

将腺病毒载体介导的基因治疗与放射治疗联合应用于体外培养的178 - 2 BMA和TSU - Pr1细胞，并分析集落形成和细胞凋亡情况。此外，对携带皮下178 - 2 BMA和TSU - Pr1肿瘤的小鼠进行联合治疗，并将肿瘤生长抑制和生存期延长情况与单一疗法（AdGlipr1/AdGLIPR1和放射治疗）或对照载体Adv/CMV/βgal进行比较，同时比较单周期治疗与两周期治疗。

结果

联合治疗在体外显著抑制集落形成并增加细胞凋亡。在体内，与单一疗法或对照相比，联合治疗显著抑制了178 - 2 BMA和TSU - Pr1肿瘤的生长并延长了生存期。联合治疗两周期后观察到进一步的肿瘤生长抑制和生存期延长。

结论

在选定的前列腺和膀胱肿瘤中，将AdGlipr1（AdGLIPR1）与放射治疗联合应用可能实现相加或协同的肿瘤控制，并且重复治疗周期可能产生额外的治疗效果。