Raiola E, Pennino F, Torre I
Dipartimento di Scienze Mediche Preventive, Università degli Studi di Napoli "Federico II", Italy.
Ann Ig. 2013 Jan-Feb;25(1):65-71. doi: 10.7416/ai.2013.19067.
In neonatal intensive care unit (NICU) invasive fungal infections are predominantly supported by Candida species, with an increasing frequency of C. non-albicans. This work aims to demonstrate the need for monitoring of these infections for the purposes of a more effective prevention strategy.
This study, conducted for 15 months on 365 patients admitted to the NICU of the University Hospital "Federico II" of Naples, examines the colonization and nosocomial infections by Candida species in relation to the most significant risk factors such as prematurity, low birth weight and the application of relief devices.
It was detected a statistically significant association between infections and pharyngeal colonization (p = 0.002), gestational age <28 weeks (p = 0.001) and central venous catheterization (p = 0.01). 12% of the 336 patients cared for more than 48 hours had pharyngeal colonization by Candida spp, especially C. albicans, while 2% develops sepsis due to C. parapsilosis.
The results demonstrate the importance and validity of the procedures used for the surveillance of infections in NICU.
在新生儿重症监护病房（NICU），侵袭性真菌感染主要由念珠菌属引起，非白色念珠菌的感染频率呈上升趋势。这项工作旨在证明为了制定更有效的预防策略而监测这些感染的必要性。
本研究在那不勒斯“费德里科二世”大学医院NICU对365名入院患者进行了15个月的研究，考察了念珠菌属的定植情况和医院感染情况，并分析了诸如早产、低出生体重和使用缓解装置等最主要的风险因素。
检测到感染与咽部定植（p = 0.002）、孕周<28周（p = 0.001）和中心静脉置管（p = 0.01）之间存在统计学上的显著关联。在336名接受护理超过48小时患者中，12%有念珠菌属咽部定植，尤其是白色念珠菌，而2%因近平滑念珠菌发生败血症。
结果证明了NICU感染监测程序的重要性和有效性。
