Ennker J, Albert A, Ennker I C
Mediclin Heart Institute Lahr/Baden, Lahr, Germany.
HSR Proc Intensive Care Cardiovasc Anesth. 2012;4(2):77-82.
The design of stentless valve prostheses is intended to achieve a more physiological flow pattern and superior hemodynamics in comparison to stented valves. First - generation stentless bioprosthesis were the Prima valve, the Freestyle valve and the Toronto stentless porcine valve. The second generation of stentless valves, as the Super stentless aortic porcine valve, need only one suture line. The Sorin Pericarbon Freedom and the Equine 3F heart Valve belong to the third generation of stentless valve pericardial bioprostheses. A stentless valve to replace a full root can be implanted by several surgical techniques: complete or modified subcoronary, root inclusion and full root. The full root technique is accompanied by the lowest incidence of patient-prothesis mismatch. Our own clinical experience reflects more than 3000 stentless valve implantations since April 1996. Randomized study trials showed a hemodynamic advantage for stentless valves, but several could not reach a significant level. Also reported was a significant advantage of stentless bioprostheses concerning transvalvular gradients, effective valve area and quicker regression of the left ventricular mass 6 months after the operation, but at 12 months. Advantages are obvious in patients with a decreased left ventricle ejection fraction of less than 50% and in smaller implanted valve size, concomitant aortic root pathology (e.g. dissection) and aortic valve endocarditis. A survival advantage for stentless bioprostheses in comparison to stented ones has been reported by all studies in the literature. Stentless valves enrich the surgical armamentarium. Time will define the place of stentless valves in the future.
与有支架瓣膜相比,无支架瓣膜假体的设计旨在实现更符合生理的血流模式和更优越的血液动力学。第一代无支架生物假体有Prima瓣膜、Freestyle瓣膜和多伦多无支架猪瓣膜。第二代无支架瓣膜,如超级无支架猪主动脉瓣膜,仅需一条缝合线。索林Pericarbon Freedom瓣膜和马源3F心脏瓣膜属于第三代无支架心包生物假体。替换整个主动脉根部的无支架瓣膜可通过多种手术技术植入:完全或改良的冠状动脉下植入、根部包埋和全根部植入。全根部植入技术导致患者与假体不匹配的发生率最低。自1996年4月以来,我们自己的临床经验涵盖了3000多例无支架瓣膜植入手术。随机研究试验显示无支架瓣膜在血液动力学方面具有优势,但有几项未达到显著水平。另据报道,无支架生物假体在跨瓣膜压差、有效瓣膜面积以及术后6个月(但不是12个月)左心室质量更快恢复方面具有显著优势。在左心室射血分数低于50%的患者、植入较小尺寸瓣膜的患者、伴有主动脉根部病变(如夹层)的患者以及主动脉瓣心内膜炎患者中,优势明显。文献中的所有研究均报道了无支架生物假体与有支架生物假体相比具有生存优势。无支架瓣膜丰富了手术器械库。时间将决定无支架瓣膜在未来的地位。