Malagrino Pamella A, Sponton Carlos H G, Esposti Rodrigo D, Franco-Penteado Carla F, Fernandes Romulo A, Bezerra Marcos André C, Albuquerque Dulcinéia M, Rodovalho Cynara M, Bacci Maurício, Zanesco Angelina
Laboratório de Fisiologia Cardiovascular e Atividade Física, Instituto de Biociências, Universidade Estadual Paulista (Unesp), Rio Claro, SP, Brasil.
Arq Bras Endocrinol Metabol. 2013 Feb;57(1):33-43. doi: 10.1590/s0004-27302013000100005.
To evaluate the influence of the interaction between endothelial nitric oxide synthase gene (NOS3) polymorphisms at positions -786T>C, Glu298Asp and intron 4b/a, and cardiorespiratory fitness on plasma nitrite/nitrate levels, blood pressure, lipid profile, and prevalence of cardiometabolic disorders.
Ninety-two volunteers were genotyped for NOS3 polymorphisms at positions (-786T>C and Glu298Asp) and (intron 4b/a) and divided according to the genotype: non-polymorphic (NP) and polymorphic (P). After that, they were subdivided according to the cardiorespiratory fitness associated with genotype: high (HNP and HP) and low (LNP and LP).
The subjects with polymorphism for the interactions at positions Glu298Asp + intron 4b/a, and Glu298Asp+-786T>C showed the highest values in total cholesterol, as well as dyslipidemia.
Our findings show that NOS3 gene polymorphisms at positions -786T>C, Glu298Asp, and intron 4b/a exert negative effects on the lipid profile compared with those who do not carry polymorphisms.
评估内皮型一氧化氮合酶基因（NOS3）-786T>C、Glu298Asp位点多态性及内含子4b/a与心肺适能的相互作用对血浆亚硝酸盐/硝酸盐水平、血压、血脂谱以及心脏代谢紊乱患病率的影响。
对92名志愿者进行NOS3基因-786T>C和Glu298Asp位点以及内含子4b/a多态性基因分型，并根据基因型分为：非多态性（NP）和多态性（P）。之后，再根据与基因型相关的心肺适能将他们进一步分为：高（HNP和HP）和低（LNP和LP）。
Glu298Asp +内含子4b/a以及Glu298Asp + -786T>C位点相互作用存在多态性的受试者总胆固醇水平最高，且存在血脂异常。
我们的研究结果表明，与未携带多态性的人相比，NOS3基因-786T>C、Glu298Asp和内含子4b/a位点的多态性对血脂谱有负面影响。
