Senior Advisor's Office, RIKEN Brain Science Institute Wako, Saitama, Japan.
Front Neural Circuits. 2013 Feb 22;7:1. doi: 10.3389/fncir.2013.00001. eCollection 2013.
Complex spikes generated in a cerebellar Purkinje cell via a climbing fiber have been assumed to encode errors in the performance of neuronal circuits involving Purkinje cells. To reexamine this notion in this review, I analyzed structures of motor control systems involving the cerebellum. A dichotomy was found between the two types of error: sensory and motor errors play roles in the feedforward and feedback control conditions, respectively. To substantiate this dichotomy, here in this article I reviewed recent data on neuronal connections and signal contents of climbing fibers in the vestibuloocular reflex (VOR), optokinetic eye movement response, saccade, hand reaching, cursor tracking, as well as some other cases of motor control. In our studies, various sources of sensory and motor errors were located in the neuronal pathways leading to the inferior olive. We noted that during the course of evolution, control system structures involving the cerebellum changed rather radically from the prototype seen in the flocculonodular lobe and vermis to that applicable to the cerebellar hemisphere. Nevertheless, the dichotomy between sensory and motor errors is maintained.
通过 climbing fiber 在小脑浦肯野细胞中产生的复杂 spikes 被认为编码了涉及浦肯野细胞的神经元回路的性能错误。在本次综述中，为了重新检验这一观点，我分析了涉及小脑的运动控制系统的结构。发现了两种类型的错误之间存在二分法：感觉错误和运动错误分别在前馈和反馈控制条件下发挥作用。为了证实这种二分法，在本文中，我回顾了最近关于前庭眼反射 (VOR)、视动眼运动反应、扫视、手伸、光标跟踪以及其他一些运动控制情况的 climbing fiber 的神经元连接和信号内容的研究数据。在我们的研究中，各种感觉和运动错误源位于通向下橄榄核的神经元通路上。我们注意到，在进化过程中，涉及小脑的控制系统结构从在绒球小结叶和蚓部中看到的原型发生了相当大的变化，适用于小脑半球。然而，感觉错误和运动错误之间的二分法仍然存在。
