[Statement: alkaline phosphatases. Genetic aspects. Identification and clinical interpretation].

The human alkaline phosphatases constitute a family of several isoenzyme forms. They are coded by 3 different structural genes. The authors find respectively the placental isoenzymes, the intestinal isoenzymes, and the isoenzymes coded by a gene called aspecific tissular. These last isoenzymes coming from the liver and the bone tissue have very similar structures leading to a very difficult differentiation and quantification. In this study, a summary is made of the main procedures at the disposal of biologist, which allows to have a differentiation of liver and bone fractions. The selected technique proposes the reactivity by affinity with a lectin. Owing to its excellent resolution, this method must contribute to a better follow-up of bone and liver metastasis and to the detection of intestinal isoenzymes, allowing the research of a possible link with different pathologies.