Jelovsek J Eric, Piccorelli Annalisa, Barber Matthew D, Tunitsky-Bitton Elena, Kattan Michael W
Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.
Female Pelvic Med Reconstr Surg. 2013 Mar-Apr;19(2):110-8. doi: 10.1097/SPV.0b013e31828508f0.
This study aimed to develop and internally validate a nomogram that facilitates decision making between patient and physician by predicting a woman's individual probability of developing urinary (UI) or fecal incontinence (FI) after her first delivery.
This study used Childbirth and Pelvic Symptoms Study data, which estimated the prevalence of postpartum UI and FI in primiparous women after vaginal or cesarean delivery. Two models were developed using antepartum variables, and 2 models were developed using antepartum plus labor and delivery variables. Urinary incontinence was defined by a response of leaking urine "sometimes" or "often" using the Medical, Epidemiological, and Social Aspects of Aging Questionnaire. Fecal incontinence was defined as any involuntary leakage of mucus, liquid, or solid stool using the Fecal Incontinence Severity Index. Logistic regression models allowing nonlinear effects were used and displayed as nomograms. Overall performance was assessed using the Brier score (zero equals perfect model) and concordance index (c-statistic).
A total of 921 women enrolled in the Childbirth and Pelvic Symptoms Study, and 759 (82%) were interviewed by telephone 6 months postpartum. Two antepartum models were generated, which discriminated between women who will and will not develop UI (Brier score = 0.19, c-statistic = 0.69) and FI (Brier score = 0.10, c-statistic = 0.67) at 6 months and 2 models were generated (Brier score = 0.18, c-statistic= 0.68 and Brier score = 0.09, c-statistic = 0.68) for predicting UI and FI, respectively, for use after labor and delivery.
These models yielded 4 nomograms that are accurate for generating individualized prognostic estimates of postpartum UI and FI and may facilitate decision making in the prevention of incontinence.
本研究旨在开发并在内部验证一种列线图,通过预测女性首次分娩后发生尿失禁(UI)或粪失禁(FI)的个体概率,来促进患者与医生之间的决策制定。
本研究使用了分娩与盆腔症状研究数据,该数据估计了初产妇经阴道或剖宫产分娩后产后UI和FI的患病率。使用产前变量开发了两个模型,使用产前加分娩变量开发了两个模型。尿失禁的定义是使用《衰老的医学、流行病学和社会方面问卷》中“有时”或“经常”漏尿的回答。粪失禁的定义是使用粪失禁严重程度指数,即任何黏液、液体或固体粪便的不自主泄漏。使用允许非线性效应的逻辑回归模型,并以列线图形式呈现。使用Brier评分(零表示完美模型)和一致性指数(c统计量)评估总体性能。
共有921名女性参与了分娩与盆腔症状研究,759名(82%)在产后6个月接受了电话访谈。生成了两个产前模型,可区分产后6个月会发生和不会发生UI(Brier评分 = 0.19,c统计量 = 0.69)和FI(Brier评分 = 0.10,c统计量 = 0.67)的女性,还生成了两个模型(Brier评分 = 0.18,c统计量 = 0.68和Brier评分 = 0.09,c统计量 = 0.68),分别用于预测分娩后发生的UI和FI。
这些模型产生了4个列线图,可准确生成产后UI和FI的个体化预后估计,可能有助于预防失禁的决策制定。